Social jet-lag potentiates obesity and metabolic syndrome when combined with cafeteria diet in rats
| Autor: | Iván Osnaya-Ramírez, Carolina Escobar, Ruud M. Buijs, Manuel Angeles-Castellanos, Mario Velasco-Ramos, Estefania Espitia-Bautista |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism media_common.quotation_subject 030209 endocrinology & metabolism Cafeteria Overweight Weight Gain 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Glucose Intolerance medicine Animals Circadian rhythm Obesity Risk factor media_common Jet Lag Syndrome Metabolic Syndrome biology business.industry Appetite medicine.disease biology.organism_classification Circadian Rhythm Diet Rats Disease Models Animal Sleep onset medicine.symptom Metabolic syndrome business Sleep 030217 neurology & neurosurgery |
| Zdroj: | Metabolism: clinical and experimental. 72 |
| ISSN: | 1532-8600 |
| Popis: | Background/Objectives Modern lifestyle promotes shifted sleep onset and shifted wake up time between weekdays and weekends, producing a condition termed “social-jet lag.” Disrupted sleep promotes increased appetite for carbohydrate and fat-rich food, which in long term leads to overweight, obesity and metabolic syndrome. In order to mimic the human situation we produced an experimental model of social-jet lag (Sj-l). With this model, we explored the link between shifted sleep time with consumption of a cafeteria diet (CafD) and the development of obesity and metabolic syndrome. Subjects/Methods The first experiment was designed to create and confirm the model of Sj-l. Rats ( n = 8–10/group) were exposed to a shifted sleep time protocol achieved by placing the rats in slow rotating wheels from Monday to Friday during the first 4 h of the light period, while on weekends they were left undisturbed. The second experiment ( n = 8–12/group) explored the combined effect of Sj-l with the opportunity to ingest CafD. All protocols lasted 12 weeks. We evaluated the development of overweight and indicators of metabolic syndrome. The statistical significance for all variables was set at P Results Sj-l alone did not affect body weight gain but induced significant changes in cholesterol in metabolic variables representing a risk factor for metabolic syndrome. Daily restricted access to CafD in the day or night induced glucose intolerance and only CafD during the day led to overweight. Sj-l combined with CafD induced overconsumption of the diet, potentiated body weight gain (16%) and promoted 5 of the criteria for metabolic syndrome including high insulin and dislipidemia. Conclusion Present data provide an experimental model of social-jet lag that combined with overconsumption of CafD, and maximized the development of obesity and metabolic syndrome. Importantly, access to CafD during the night did not lead to overweight nor metabolic syndrome. |
| Databáze: | OpenAIRE |
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