Directly Thiolated Modification onto the Surface of Detonation Nanodiamonds
| Autor: | Hsueh Liang Chu, Ming Hua Hsu, Ying Pei Huang, Dian Syue Wu, Jiun Yu Chen, Hong Chuang, Su Chin Huang, Chia-Ching Chang, Chien-Chung Han, Jen Kun Chen, Fong Yu Cheng |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
Cell Survival Photoelectron Spectroscopy Detonation Metal Nanoparticles Nanotechnology Detonation nanodiamond Nanodiamonds Microscopy Electron Transmission X-ray photoelectron spectroscopy Colloidal gold Elemental analysis Transmission electron microscopy Cell Line Tumor Humans Surface modification General Materials Science Gold Sulfhydryl Compounds Particle Size Nanodiamond |
| Zdroj: | ACS Applied Materials & Interfaces. 6:7198-7203 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/am500324z |
| Popis: | An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds. |
| Databáze: | OpenAIRE |
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