Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson’s disease
| Autor: | Alessandro Stefani, Antonio Pisani, Atticus H. Hainsworth, Mariangela Pierantozzi, Salvatore Galati, Vincenzo Moschella, G. Lunardi, Paolo Stanzione, Silvia Rossi, Livia Brusa, Francesco Fornai, Domenicantonio Tropepi, Ernesto Fedele |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
3 4-Dihydroxyphenylacetic Acid Age of Onset Aged Disease Progression Dopamine Dyskinesias Homovanillic Acid Humans Middle Aged Parkinson Disease Parkinson's disease Disease Negative exponential Correlation chemistry.chemical_compound Cerebrospinal fluid 4-Dihydroxyphenylacetic Acid Internal medicine medicine Dyskinesia Homovanillic acid medicine.disease Dopamine turnover Parkinson's disease progression Endocrinology Neurology chemistry Settore MED/26 - Neurologia Neurology (clinical) Geriatrics and Gerontology medicine.symptom Psychology medicine.drug |
| Popis: | To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced with dyskinesias (DYS). DA, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly higher in DEN patients compared with other groups. A negative exponential correlation related DA level and disease duration. The HVA/DA ratio was significantly higher in the ADV and DYS group than that found in DEN group. Our data show that disease progression produces an early large decay of DA levels, followed by a stabilization. On the contrary, a late change in DA turnover (increased HVA/DA ratio) is documented in patients with longer disease duration. Our results suggest that the appearance of dyskinesia may not be related to a further loss of DA terminals but to a different, abnormal, DA turnover. |
| Databáze: | OpenAIRE |
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