Testicular Adrenal Rest Tumors in Patients with Congenital Adrenal Hyperplasia
| Autor: | Fatma Şentürk Mutlu, Ömer Tarım, Aliye Özlem Paşa, Esra Deniz Papatya Cakir, Halil Saglam, Erdal Eren |
|---|---|
| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Endokrinoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı., Çakır, Esra Deniz Papatya, Mutlu, Fatma Şentürk, Eren, Erdal, Paşa, Aliye Özlem, Sağlam, Halil, Tarım, Ömer, C-7392-2019, AAM-1734-2020, AAH-1155-2021 |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Leuprorelin Adrenal Rest Tumor Hydrocortisone Endocrinology Diabetes and Metabolism Tumor diagnosis Pediatrics Endocrinology Glucocorticoid Adrenal Cortex Tumor Congenital Adrenal Hyperplasia Testicular Neoplasms Prevalence Child Endocrinology & metabolism Ultrasonography Androstenedione blood level Anthropometry Cyproterone acetate 17-alpha-Hydroxyprogesterone Bone age medicine.anatomical_structure Treatment Outcome Fludrocortisone Radiologist Child Preschool Testicular adrenal rest tumors Scrotum Gynecomastia Original Article Human Infertility Adult medicine.medical_specialty Adolescent Clinical article Urology Adrenocorticotropic hormone Article Age Descriptive research Adrenocorticotropic Hormone Hydroxyprogesterone Steroid 21 monooxygenase deficiency Age Determination by Skeleton medicine congenital adrenal hyperplasia Humans Congenital adrenal hyperplasia Clinical evaluation Androstenedione testicular microlithiasis Growth hormone Adrenal cortex tumor Gynecology Testis tumor Adrenal Hyperplasia Congenital business.industry Infant Follow up medicine.disease Tamoxifen Preschool child Pediatrics Perinatology and Child Health Virilization Corticotropin Cancer patient School child Echography Steroid 21-Hydroxylase Salt wasting business Hormone blood level Controlled study Testicular microlithiasis Follow-Up Studies |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5735 1308-5727 |
| Popis: | Objective: Early diagnosis and treatment of testicular adrenal rest tumors (TART) is important for gonadal functions and fertility protection in boys with congenital adrenal hyperplasia (CAH). In this descriptive study, we investigated the prevalence of TART in boys with 21-hydroxylase deficient (21OHD) CAH followed in our pediatric endocrine clinic. Methods: The study group consisted of 14 male patients with a mean age of 9.6±5.1 (range: 0.8-18.3) years. Six (42.9%) of the 14 patients were diagnosed as having salt-wasting type (SW) and eight (57.1%) patients - as having the simple virilizing (SV) form of 21OHD. Mean age at diagnosis was 2.9±2.7 (range: 0.03-6.3) years. Two different radiologists performed scrotal ultrasonography. Chronological age, bone age, and anthropometric measurements were evaluated. Serum adrenocorticotropic hormone (ACTH), 17-alpha-hydroxyprogesterone (17OHP) and androstenedione levels were also evaluated in all patients during the follow-up period. Results: Scrotal ultrasonography revealed bilateral TART in two patients (14.3%) and testicular microlithiasis (TM) in four patients (28.6%). One patient had both TART and TM bilaterally. During the follow-up period, the mean serum adrenocorticotropic hormone, 17OHP and androstenedione levels in the total group of patients were 130.0±179.1 pg/mL (21.7-726.5), 5.8±3.3 ng/mL (0.8-11.4) and 4.3±4.1 (0.2-11.0) ng/mL, respectively. Conclusions: Microlithiasis or TART may be frequently encountered during the follow-up of patients with CAH. In order to prevent late complications including infertility, we suggest that ultrasonographic evaluations be performed yearly in all male CAH patients. Conflict of interest:None declared. |
| Databáze: | OpenAIRE |
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