Noninvasive mesoscopic imaging of actinic skin damage using spatial frequency domain imaging
| Autor: | Nathan M. Weir, Ulas Sunar, Daniel Rohrbach, Faye Hager, Elizabeth Cates, Chien Poon, Jeffrey B. Travers |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Population 01 natural sciences Article 010309 optics 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Optical coherence tomography 0103 physical sciences medicine education Skin damage education.field_of_study medicine.diagnostic_test business.industry Actinic keratosis Cancer medicine.disease Domain imaging Atomic and Molecular Physics and Optics Diffuse optical imaging Spatial frequency business Biotechnology |
| Zdroj: | Biomedical Optics Express. 8:3045 |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.8.003045 |
| Popis: | For prevention and accurate intervention planning, it is crucial to predict if lesions will progress towards cancer. In this study, we investigated the change in optical properties and vascular parameters to characterize skin tissue from mild photodamage to actinic keratosis (AK). Multi-wavelength spatial frequency domain imaging (SFDI) measurements were performed on three patients with clinically normal skin, as well as pre-cancerous actinic keratosis lesions. Our results indicate that there exist significant differences in both optical and vascular parameters between these patients, and that these parameters can be early biomarkers of neoplasia. Ultimately, clinicians can use this noninvasive approach for frequent monitoring of high-risk population. |
| Databáze: | OpenAIRE |
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