Prospects for Radiopharmaceuticals as Effective and Safe Therapeutics in Oncology and Challenges of Tumor Resistance to Radiotherapy
| Autor: | Nikolai Zhelev, Ekaterina Nikolova, Dimitar Tonev, Vladimir Neychev |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Health Toxicology and Mutagenesis medicine.medical_treatment Radio resistance Review Toxicology Tumor resistance radio-sensitivity 03 medical and health sciences 0302 clinical medicine Internal medicine medicine cancer radiopharmaceuticals Chemical Health and Safety business.industry lcsh:RM1-950 Public Health Environmental and Occupational Health apoptosis Radio sensitivity Radiation therapy 030104 developmental biology lcsh:Therapeutics. Pharmacology radio-resistance 030220 oncology & carcinogenesis business |
| Zdroj: | Dose-Response, Vol 19 (2021) Dose-Response |
| ISSN: | 1559-3258 |
| Popis: | The rapid advances in nuclear medicine have resulted in significant advantages for the field of oncology. The focus is on the application of radiopharmaceuticals as therapeuticals. In addition, the latest developments in cell biology (the understanding of the cell structure, function, metabolism, genetics, signaling, transformation) have given a strong scientific boost to radiation oncology. In this regard, the article discusses what is soon going to be a new jump in radiation oncology based on the already accumulated considerable knowledge at the cellular level about the mechanisms of cell transformation and tumor progression, cell response to radiation, cell resistance to apoptosis and radiation and cell radio-sensitivity. The mechanisms of resistance of tumor cells to radiation and the genetically determined individual sensitivity to radiation in patients (which creates the risk of radiation-induced acute and late side effects) are the 2 major challenges to overcome in modern nuclear medicine. The paper focuses on these problems and makes a detailed summary of the significance of the differences in the ionizing properties of radiopharmaceuticals and the principle of their application in radiation oncology that will shed additional light on how to make the anti-cancer radiotherapies more efficient and safe, giving some ideas for optimizations. |
| Databáze: | OpenAIRE |
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