Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation
| Autor: | Sally Horne-Badovinac, Olivier Bardot, H. Alegot, Vincent Mirouse, F. Cerqueira Campos, Cynthia Dennis, Adam J. Isabella, Pierre Pouchin, Cornelia Fritsch |
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| Přispěvatelé: | Génétique, Reproduction et Développement (GReD ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), ANR-16-IDEX-0001,CAP 20-25,CAP 20-25(2016) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Morphogenesis macromolecular substances Fibril Basement Membrane Extracellular matrix Animals Genetically Modified Dystrophin 03 medical and health sciences 0302 clinical medicine Dystroglycan medicine Animals Dystroglycans Molecular Biology Actin Cytoskeleton 030304 developmental biology Basement membrane 0303 health sciences biology Chemistry Cell Polarity Planar cell polarity Actins Dystroglycan complex Actin Cytoskeleton medicine.anatomical_structure Multiprotein Complexes biology.protein Biophysics Drosophila Female Elongation 030217 neurology & neurosurgery Developmental Biology Tissue elongation Research Article Protein Binding |
| Zdroj: | Development Development (Cambridge, England) Development (Cambridge, England), Company of Biologists, 2020, 147 (7), pp.dev186957. ⟨10.1242/dev.186957⟩ Development (Cambridge, England), 2020, 147 (7), pp.dev186957. ⟨10.1242/dev.186957⟩ |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.186957⟩ |
| Popis: | SummaryHow extracellular matrix participates to tissue morphogenesis is still an open question. In theDrosophilaovarian follicle, it has been proposed that after Fat2-dependent planar polarization of the follicle cell basal domain, oriented basement membrane (BM) fibrils and F-actin stress fibers constrain follicle growth, promoting its axial elongation. However, the relationship between BM fibrils and stress fibers and their respective impact on elongation are unclear. We found that Dystroglycan (Dg) and Dystrophin (Dys) are involved in BM fibril deposition. Moreover, they orient stress fibers, by acting locally and in parallel to Fat2. Nonetheless, Dg-Dys complex-mediated cell autonomous control of F-actin fibers orientation relies on the previous BM fibril deposition, indicating two distinct but interdependent functions. Thus, the Dg-Dys complex works as a critical organizer of the epithelial basal domain, regulating both F-actin and BM. Furthermore, BM fibrils act as a persistent cue for the orientation of stress fibers that are the main effector of elongation. |
| Databáze: | OpenAIRE |
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