Nailfold capillaroscopy in SSc : innocent bystander or promising biomarker for novel severe organ involvement/progression?
| Autor: | Vanhaecke, Amber, Cutolo, Maurizio, Distler, Oliver, Riccieri, Valeria, Allanore, Yannick, Denton, Christopher P, Hachulla, Eric, Ingegnoli, Francesca, Deschepper, Ellen, Avouac, Jérôme, Jordan, Suzana, Launay, David, Melsens, Karin, Pizzorni, Carmen, Sulli, Alberto, Vasile, Massimiliano, Herrick, Ariane L, Smith, Vanessa |
|---|---|
| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
INVOLVEMENT
RAYNAUDS-PHENOMENON organ involvement microcirculation 610 Medicine & health PROGRESSION INTERSTITIAL LUNG-DISEASE CLASSIFICATION Microscopic Angioscopy disease progression Rheumatology Medicine and Health Sciences EULAR Study Group on Microcirculation in Rheumatic Diseases Humans Pharmacology (medical) EUSTAR Scleroderma Systemic nailfold videocapillaroscopy SYSTEMIC-SCLEROSIS 10051 Rheumatology Clinic and Institute of Physical Medicine MICROVASCULAR DAMAGE Capillaries Nails Scleroderma Diffuse RELIABILITY Female VIDEOCAPILLAROSCOPY ASSESSMENT EULAR SCLERODERMA TRIALS Biomarkers SSc |
| Zdroj: | RHEUMATOLOGY |
| ISSN: | 1462-0324 1462-0332 |
| Popis: | Objectives Nailfold videocapillaroscopy (NVC) plays a well-established role in differentiating primary from secondary RP due to SSc. However, the association of NVC with novel severe organ involvement/progression in SSc has never been evaluated in a multicentre, multinational study, which we now perform for the first time. Methods Follow-up data from 334 SSc patients [265 women; 18 limited SSc (lSSc)/203 lcSSc/113 dcSSc] registered between November 2008 and January 2016 by seven tertiary centres in the EUSTAR-database, were analysed. Novel severe organ involvement/progression was defined as new/progressive involvement of the peripheral vasculature, lungs, heart, skin, gastrointestinal tract, kidneys, musculoskeletal system, or death, at the 12- or 24-month follow-up. NVC images at enrolment were quantitatively and qualitatively evaluated according to the standardized definitions of the EULAR Study Group on Microcirculation in Rheumatic Diseases. Uni- and multivariable logistic regression modelling (ULR, MLR) was performed. Results Of the 334 included SSc patients, 257 (76.9%) developed novel overall severe organ involvement/progression. Following MLR, normal capillary density was associated with less-frequent novel overall severe organ involvement/progression [odds ratio (OR) = 0.77, P Conclusions Our results suggest that NVC may be a promising biomarker in SSc, certainly warranting further investigation. Despite the participation of tertiary centres, which follow their patients in a standardized way, we were underpowered to detect associations with infrequent severe organ involvement/progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|