Role of impaired DNA repair in genotoxic susceptibility of patients with head and neck cancer
| Autor: | Aleksandra Golinska, Karolina Przybyłowska, Alina Morawiec-Bajda, Jurek Olszewski, Pawel Rusin, Dariusz Kaczmarczyk, Ireneusz Majsterek |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
medicine.medical_specialty DNA Repair DNA repair business.industry DNA damage Health Toxicology and Mutagenesis Head and neck cancer Case-control study Cell Biology Toxicology medicine.disease Head and neck squamous-cell carcinoma Metastasis Head and Neck Neoplasms Internal medicine Case-Control Studies Cancer cell medicine Carcinoma Carcinoma Squamous Cell Humans business DNA Damage Mutagens |
| Zdroj: | Cell biology and toxicology. 25(5) |
| ISSN: | 1573-6822 |
| Popis: | DNA repair is critical for genotoxic susceptibility and cancer development. Forty-seven patients with head and neck squamous cell carcinoma (HNSCC) and 38 healthy controls were enrolled in this study. Among the patients, 16 subjects had metastasis of HNSCC. The extent of DNA damage, including oxidative lesions, and efficiency of repair after genotoxic treatment with hydrogen peroxide were examined using the alkaline comet assay. HNSCC cells were sensitive to genotoxic treatment and displayed impaired DNA repair. In particular, lesions caused by hydrogen peroxide were repaired less effectively in cancer cells from patients with metastasis than in cells from healthy controls. We suggest that impaired DNA repair might play a role in genotoxic susceptibility of patients with head and neck cancer. Finally, as a consequence of this finding we have shown that treatment with DNA-reactive drugs could be considered as an effective therapy strategy for head and neck cancer. |
| Databáze: | OpenAIRE |
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