Indolyl- and Pyrrolylazine Derivatives Cause the Accumulation of Heat Shock Protein Hsp70 in Sh-Sy5Y Human Neuroblastoma Cells

Autor:	Vladimir F. Lazarev, Irina V. Guzhova, Marina A. Mikeladze, Boris A. Margulis, Irina A. Utepova, Elena R. Mikhaylova, O. N. Chupakhin, M. A. Trestsova
Rok vydání:	2020
Předmět:	Neurons SH-SY5Y Indoles Chemistry Cell Biophysics General Chemistry General Medicine Biochemistry Small molecule Cell biology Hsp70 Neuroblastoma cell Neuroblastoma medicine.anatomical_structure Heat shock protein Cell Line Tumor Toxicity medicine Humans Inducer HSP70 Heat-Shock Proteins Pyrroles
Zdroj:	Doklady. Biochemistry and biophysics. 494(1)
ISSN:	1608-3091
Popis:	The heat shock protein Hsp70 is involved in cell defense from various types of stress, including the proteotoxic stress, which occurs during the development of many neurodegenerative diseases. This work presents data on the detection of small molecules, derivatives of indolyl- and pyrrolylazines, which can activate the synthesis of Hsp70 and cause its accumulation in the cell. The toxicity level of the new Hsp70 synthesis inducers was evaluated, and the safety of these compounds was demonstrated in experiments on SH-SY5Y neuroblastoma cell line. Derivatives of indolyl- and pyrrolylazines presented in this work can be potential therapeutic agents in models of neurodegenerative diseases that should be studied in more detail.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039f93d2bb2739e124a40ddbfd927cb5 https://pubmed.ncbi.nlm.nih.gov/33119827 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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