Safflower injection inhibits pulmonary arterial remodeling in a monocrotaline-induced pulmonary arterial hypertension rat model

Autor: Xu Jianpu, Shibiao Ding, Liangliang Kong, Fei He, Xu'ai Lin, Ru Chuhui, Aifeng Chen
Rok vydání: 2020
Předmět:
Male
Integrins
medicine.medical_specialty
medicine.medical_treatment
Myocytes
Smooth Muscle
Carthamus tinctorius
Connective tissue
Blood Pressure
030204 cardiovascular system & hematology
General Biochemistry
Genetics and Molecular Biology
Injections
Rats
Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Transforming Growth Factor beta
Arteriole
Right ventricular hypertrophy
Edema
Internal medicine
medicine.artery
medicine
Animals
Lung
Cells
Cultured
Cell Proliferation
Pulmonary Arterial Hypertension
Monocrotaline
Dose-Response Relationship
Drug
Ventricular Remodeling
business.industry
Myocardium
Growth factor
Cardiac muscle
medicine.disease
Fibronectins
Rats
medicine.anatomical_structure
030220 oncology & carcinogenesis
Pulmonary artery
Cardiology
Vascular resistance
Collagen
medicine.symptom
business
Drugs
Chinese Herbal
Zdroj: Zeitschrift für Naturforschung C. 76:27-34
ISSN: 1865-7125
0939-5075
DOI: 10.1515/znc-2020-0004
Popis: Pulmonary arterial hypertension (PAH) is a group of diseases with an increase of pulmonary artery pressure (PAP) and pulmonary vascular resistance. Here, the effects of safflower injection, a preparation of Chinese herbs, was investigated in a monocrotaline (MCT)-induced PAH rat model. PAP, carotid artery pressure (CAP), and the right ventricular hypertrophy index (RVHI) increased in the PAH group, while safflower injection was able to inhibit this increase to similar levels as observed in the normal group. The arteriole wall of the lungs and cardiac muscle were thickened and edema was observed in the PAH group, while these pathologies were improved in the herb-treated group in a dose-dependent manner. MCT treatment induced proliferation of pulmonary artery smooth muscle cells (PASMCs), which was inhibited by safflower injection in a dose-dependent manner. Our experimental results demonstrated that safflower injection can regulate pulmonary arterial remodeling through affecting the expression of connective tissue growth factor, transforming growth factor-β, integrin, collagen or fibronectin, which subsequently affected the thicknesses of the arteriole walls of the lungs and cardiac muscle, and thereby benefits the control of PAH. This means safflower injection improved the abnormalities in PAP, CAP and RVHI, and pulmonary arterial remodeling through regulation of remodeling factors.
Databáze: OpenAIRE
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