Les tumeurs thoraciques SMARCA4 déficientes : une nouvelle entité
| Autor: | Elise Decroix, Diane Damotte, Audrey Mansuet-Lupo, M. Wislez, Karen Leroy, Ludovic Fournel, Marco Alifano |
|---|---|
| Přispěvatelé: | Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CCSD, Accord Elsevier |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research [SDV]Life Sciences [q-bio] medicine.medical_treatment NSCLC Targeted therapy 03 medical and health sciences BRG1 0302 clinical medicine SMARCA4 Carcinoma medicine Radiology Nuclear Medicine and imaging CBNPC business.industry EZH2 Hematology General Medicine Immunotherapy medicine.disease Phenotype 3. Good health Chromatin [SDV] Life Sciences [q-bio] 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Sarcoma business SWI/SNF complex |
| Zdroj: | Bulletin du Cancer Bulletin du Cancer, John Libbey Eurotext, 2020, 107, pp.41-47. ⟨10.1016/j.bulcan.2019.12.001⟩ |
| ISSN: | 0007-4551 1769-6917 |
| Popis: | International audience; A growing number of studies suggest a tumor suppressor role for the SWI/SNF complex involved in the remodeling of chromatin. Alterations of this complex have been found in many tumors of different origins, with topographic, morphologic and phenotypic diversity. Notably, they define 2 types of thoracic tumors: SMARCA4-deficient non-small cell lung carcinoma and SMARCA4-deficient sarcoma. Some clinical features appear to be common to both, such as intrathoracic localization, smoking exposure, male predominance and poor prognosis. However, the histological distinction between these two entities is sometimes difficult and it is not excluded that these entities belong to the same tumor spectrum with different degrees of differentiation. The therapy of these tumors is not yet codified. These tumors do not seem associated with oncogenic driver mutations allowing the prescription of targeted therapy, but immunotherapy has been shown to be effective in rare reported cases. More specific treatments using EZH2 inhibitors also seem promising in SMARCA4 deficient sarcomas. |
| Databáze: | OpenAIRE |
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