Supplemental Figures S1-S13 and Tables S1-S3 from Targeting MUC1-C Inhibits TWIST1 Signaling in Triple-Negative Breast Cancer

Autor: Donald Kufe, Mehmet Samur, Hidekazu Takahashi, Yozo Suzuki, Takahiro Maeda, Masayuki Hiraki, Masaaki Miyo, Deli Hong, Yota Yasumizu, Wei Li, Ling Kui, Yan Zhang, Rehan Ahmad, Caining Jin, Masaaki Yamamoto, Hasan Rajabi, Tsuyoshi Hata
Rok vydání: 2023
DOI: 10.1158/1535-7163.22504599.v1
Popis: Supplemental Figure S1. Targeting NF-kappaB p65 has little effect on TWIST1 expression; Supplemental Figure S2. Targeting MUC1-C is not associated with regulation of STAT3 mRNA levels; Supplemental Figure S3. Targeting STAT3 genetically or pharmacologically decreases TWIST1 expression; Supplemental Figure S4. MUC1-C and STAT3 form a nuclear complex; Supplemental Figure S5. Hallmark pathway analysis for BT-549 cells; Supplemental Figure 6. Hallmark pathway analysis for SUM149 cells; Supplemental Figure S7. Metacore adherens junction disassembly and EMT pathway analysis for BT-549 cells; Supplemental Figure S8. Metacore EMT pathway analysis for SUM149 cells; Supplemental Figure S9. Silencing MUC1-C inhibits cell invasive capacity; Supplemental Figure S10. Silencing MUC1-C inhibits growth of BT-549 and SUM149 cells; Supplemental Figure S11. Silencing MUC1-C inhibits colony formation of SUM149 cells; Supplemental Figure S12. Downregulation of MUC1-C and TWIST1 expression in vivo; Supplemental Figure S13. Selection of BT-549 cells for PTX resistance; Supplemental Table S1: Primers sequences for qRT-PCR; Supplemental Table S2: Primers used in ChIP assays; Supplemental Table S3: Combination FA and CI values.
Databáze: OpenAIRE