Predictors of renal damage in systemic lupus erythematous patients: data from a multiethnic, multinational Latin American lupus cohort (GLADEL)
| Autor: | Margarita Portela-Hernández, Nilzio Antônio da Silva, Manuel F. Ugarte-Gil, Enrique R. Soriano, Loreto Massardo, M I Segami, Oscar Neira, Luis H. Silveira, Guillermo J. Pons-Estel, Mary-Carmen Amigo, Cristina Reátegui-Sokolova, Marlene Guibert-Toledano, Mónica P. Sacnun, Verónica Saurit, Rosana Quintana, Gloria Vásquez, Rosa Chacón-Diaz, Bernardo A. Pons-Estel, Eduardo Ferreira Borba Neto, Graciela S. Alarcón, María H Esteva-Spinetti, Emilia Inoue Sato, Eloisa Bonfa, Francisco Caeiro, Guillermo A. Berbotto, Alejandro Alvarellos, Daniel Wojdyla, Ana Carolina de Oliveira e Silva Montandon, Ignacio García-De La Torre, Luis J. Catoggio, Rosa M Serrano-Morales, Gil Reyes-Llerena, Mario H. Cardiel, Guillermina B Harvey, Fernando Cavalcanti, Leonor A Barile-Fabris, Mercedes A. García |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Immunology Lupus nephritis Lupus lcsh:Medicine urologic and male genital diseases Gastroenterology Autoimmune Diseases Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Prednisone Internal medicine medicine Humans Lupus Erythematosus Systemic Immunology and Allergy 030212 general & internal medicine 030203 arthritis & rheumatology Creatinine Systemic lupus erythematosus Proteinuria Lupus erythematosus Lupus Erythematosus Red Cell business.industry Systemic lcsh:R medicine.disease Lupus Nephritis Latin America chemistry Cohort medicine.symptom business medicine.drug |
| Zdroj: | RMD Open, Vol 6, Iss 3 (2020) RMD Open |
| ISSN: | 2056-5933 |
| Popis: | AimA decrease in proteinuria has been considered protective from renal damage in lupus nephritis (LN), but a cut-off point has yet to be established. The aim of this study was to identify the predictors of renal damage in patients with LN and to determine the best cut-off point for a decrease in proteinuria.MethodsWe included patients with LN defined clinically or histologically. Possible predictors of renal damage at the time of LN diagnosis were examined: proteinuria, low complement, anti-double-stranded DNA antibodies, red cell casts, creatinine level, hypertension, renal activity (assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)), prednisone dose, immunosuppressive drugs and antimalarial use. Sociodemographic variables were included at baseline. Proteinuria was assessed at baseline and at 12 months, to determine if early response (proteinuria ResultsFive hundred and two patients with systemic lupus erythematosus patients were included; 120 patients (23.9%) accrued renal damage during their follow-up. Early response to treatment (HR=0.58), antimalarial use (HR=0.54) and a high SES (HR=0.25) were protective of renal damage occurrence, whereas male gender (HR=1.83), hypertension (HR=1.86) and the renal component of the SLEDAI (HR=2.02) were risk factors for its occurrence.ConclusionsEarly response, antimalarial use and high SES were protective of renal damage, while male gender, hypertension and higher renal activity were risk factors for its occurrence in patients with LN. |
| Databáze: | OpenAIRE |
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