Implication of chemo‐resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy

Autor: Yoshihiko Hirohashi, Emi Mizushima, Munehide Nakatsugawa, Noriyuki Sato, Makoto Emori, Toshihiko Torigoe, Takayuki Kanaseki, Tomohide Tsukahara, Yuji Shibayama, Toshihiko Yamashita, Kenji Murata, Terufumi Kubo
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Cancer Research
sarcoma
Lymphocyte
medicine.medical_treatment
CD8-Positive T-Lymphocytes
Basic and Clinical Immunology
0302 clinical medicine
Tumor Cells
Cultured
Medicine
Child
Aged
80 and over
education.field_of_study
General Medicine
Middle Aged
medicine.anatomical_structure
Oncology
Child
Preschool
030220 oncology & carcinogenesis
Original Article
Female
Sarcoma
Adult
Adolescent
Population
Antineoplastic Agents
Young Adult
03 medical and health sciences
Antigen
Antigens
Neoplasm
Immunity
Chemotherapy
Humans
young memory
education
Aged
business.industry
Original Articles
stem cell memory
peripheral blood
medicine.disease
030104 developmental biology
Drug Resistance
Neoplasm
Case-Control Studies
Immunology
business
Immunologic Memory
Memory T cell
CD8
T-Lymphocytes
Cytotoxic
Zdroj: Cancer Science
ISSN: 1349-7006
1347-9032
Popis: Chemotherapy has improved the prognosis of patients with sarcomas. However, it may suppress anti-tumor immunity. Recently, we reported a novel CD8+ memory T cell population with a chemo-resistance property, “young memory” T (TYM) cells. In this study, we investigated the proportion and function of TYM cells in peripheral blood of healthy donors and sarcoma patients who received chemotherapy and those who did not. The proportion of TYM cells was significantly decreased in patients compared with that in healthy donors. In healthy donors, anti-EBV CTLs were induced using mixed lymphocyte peptide culture, from not only TYM cells but also TCM and TEM cells. No CTLs directed to tumor-associated antigens were induced. In sarcoma patients who did not receive chemotherapy, in addition to anti-EBV CTLs, CTLs directed to the tumor-associated antigen PBF were induced from TYM, TCM and TEM cells. In sarcoma patients who received chemotherapy, EBV-specific CTLs were induced from TYM cells but were hardly induced from TEM cells. Interestingly, CTLs directed to the anti-tumor-associated antigen PBF were induced from TYM cells but not from the TCM and TEM cells in sarcoma patients who received chemotherapy. The findings suggest that TYM cells are resistant to chemotherapy and can firstly recover from the nadir. TYM cells might be important for immunological memory, especially in sarcoma patients receiving chemotherapy. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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