A rabbit model of age-dependant ocular hypertensive response to topical corticosteroids
| Autor: | Wai Ying Li, Dennis S.C. Lam, Dorothy S. P. Fan, Chi Pui Pang, Kwong Wai Choy, D. T. L. Liu, Thomas Y. H. Chiu, Yi Qin, Shi Lam, Gary Hin-Fai Yam |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Rimexolone Intraocular pressure medicine.medical_specialty genetic structures Administration Topical Glaucoma Ocular hypertension Balanced salt solution Dexamethasone Masson's trichrome stain Tonometry Ocular Trabecular Meshwork Pregnadienes Ophthalmology Animals Medicine Glucocorticoids Intraocular Pressure Fluorometholone Extracellular Matrix Proteins business.industry Loteprednol Etabonate Age Factors General Medicine medicine.disease eye diseases Androstadienes Disease Models Animal medicine.anatomical_structure Ocular Hypertension Rabbits sense organs Trabecular meshwork Ophthalmic Solutions business medicine.drug |
| Zdroj: | Acta Ophthalmologica. 90:559-563 |
| ISSN: | 1755-375X |
| DOI: | 10.1111/j.1755-3768.2010.02016.x |
| Popis: | Objective: To investigate the ocular hypertensive response to topical dexamethasone (DEX), rimexolone (RIM), loteprednol etabonate (LOT) and fluorometholone (FML) in rabbits of different ages. Methods: Seventy-five rabbits of three age groups (7 weeks, 6 months and 1-year old) received topical administration of 0.1% DEX, 1% RIM, 0.5% LOT, 0.1% FML or balanced salt solution four times daily for 1 month. Intraocular pressure (IOP) was monitored at regular time intervals. After a month, eyes were harvested for histological study with haematoxylin and eosin (H&E), periodic acid Schiff and Masson trichrome staining. Trabecular meshwork changes were graded by masked ocular pathologists. Results: Topical DEX caused the greatest increase in IOP, followed by RIM and FML. LOT caused the least IOP increase. Similar pattern of IOP response to the four corticosteroids was observed in the three studied age groups. Young rabbits (7 week) were the most responsive to corticosteroids among the age groups. Extracellular matrix thickening in the trabecular meshwork region and loss of trabecular meshwork cells were observed after DEX, FML or RIM treatments. Conclusion: Young rabbits are more susceptible to steroid induced increase in IOP, even for milder steroids such as fluorometholone and rimexolone. |
| Databáze: | OpenAIRE |
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