Use of Gentamicin for Sepsis and Septic Shock in Anaesthesia-Intensive Care Unit: A Clinical Practice Evaluation
| Autor: | Patrick Gerome, Andrei Cividjian, Antoine Lamblin, Cyril Pernod, Wey Pierre-François |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Creatinine
Septic shock business.industry peak plasma concentration (Cmax) Intensive Care Cmax Context (language use) gentamicin Corrective formula medicine.disease intensive care unit Intensive care unit law.invention sepsis Sepsis chemistry.chemical_compound chemistry law Anesthesia medicine Original Article Gentamicin Medical prescription business medicine.drug |
| Zdroj: | Turkish Journal of Anaesthesiology and Reanimation |
| ISSN: | 2667-6370 |
| DOI: | 10.5152/tjar.2019.57255 |
| Popis: | Objective Numerous cases of gentamicin underdosing have been described in the literature in the context of sepsis and septic shock in anaesthesia-intensive care units (ICU). A survey of clinical practice was conducted with the aim to rationalise the use of gentamicin in the unit. The secondary objective was to propose a corrective formula for adjusting individual dosage. Methods A single-centre survey was used to determine the initial dose of gentamicin administered, in an anaesthesia-ICU, during the first hours of sepsis/septic shock. An initial retrospective phase allowed focusing on the points of improvement in terms of prescription. A second prospective phase enabled the evaluation of benefits following the implemented changes. Results Fifty-one patients were included during the retrospective phase (2014–2015) and 28 patients during the prospective phase (2016–2017). Out-of-guideline prescriptions significantly decreased between these two study periods (i.e., pulmonary infections decreased from 70.5% to 18%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|