Serum prolidase enzyme activity and oxidative status in patients with Behçet's disease
| Autor: | Serda Em, Hatice Yüksel, Mehmet Yıldız, Kemal Nas, Pelin Oktayoglu, Mehtap Bozkurt, Dicle Akdeniz |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Dipeptidases Physiology Clinical Biochemistry Behcet's disease Oxidative phosphorylation medicine.disease_cause Biochemistry Gastroenterology Antioxidants chemistry.chemical_compound Young Adult Internal medicine Malondialdehyde Healthy control Medicine Humans In patient Research Articles biology business.industry Behcet Syndrome Biochemistry (medical) Cell Biology medicine.disease Enzyme assay Oxidative Stress chemistry Immunology biology.protein Population study Female Lipid Peroxidation business Oxidative stress |
| Zdroj: | Redox report : communications in free radical research. 19(2) |
| ISSN: | 1743-2928 |
| Popis: | Objectives To assess serum prolidase enzyme activity and oxidative stress in patients with Behçet's disease (BD). Methods The study population consisted of BD patients (n = 42) and healthy participants (n = 29). BD patients were classified as active (n = 18) or inactive (n = 24) according to disease activity. Serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and malondialdehyde (MDA) levels were measured. Results In BD patients with active disease, serum prolidase activity was significantly higher compared with the inactive and control participants. Serum prolidase activity was also significantly higher in all BD patients in comparison with controls. Serum prolidase activity was also positively correlated with OSI, C-reactive protein, and active BD. MDA, TOS, and OSI levels were all significantly higher in the BD group when compared with the healthy control participants. Serum TAS levels were significantly lower in BD patients in comparison with healthy controls. Conclusion High prolidase activity may indicate critical biological activities relevant to pathological events in BD, and this activity may be a biological indicator of disease. Further studies are needed to verify these findings. |
| Databáze: | OpenAIRE |
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