Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
| Autor: | Hilde Jansens, Viggo Van Tendeloo, Nathalie Cools, Elke Leuridan, Evelien Smits, K. Bergs, Pieter Meysman, Steven Heynderickx, Benson Ogunjimi, Niel Hens, P. Beutels, Kris Laukens, Herman Goossens, J. Van den Bergh, P. Van Damme, Alex Vorsters |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine Herpesvirus 3 Human medicine.medical_specialty Time Factors Science viruses Congenital cytomegalovirus infection Cytomegalovirus Antibodies Viral Virus 03 medical and health sciences Chickenpox Immune system Immunity Epidemiology medicine Longitudinal Studies Multidisciplinary biology integumentary system business.industry virus diseases Grandparent biochemical phenomena metabolism and nutrition medicine.disease Grandparents 030104 developmental biology Immunoglobulin G Immunology biology.protein Medicine Human medicine Antibody business Mathematics |
| Zdroj: | Scientific reports Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. The resulting 183 samples and those of 14 controls were assessed for VZV-specific T-cell immunity and antibody titres. The percentages of VZV-specific CD4+ IL-2-producing T-cells were increased in reexposed grandparents compared to control participants up to 9 months after re-exposure. Using a longitudinal mixture modelling approach, we found that 25% and 17% of re-exposed grandparents showed a boosting of VZV-specific CD4+ IL-2-producing T-cells and VZV-specific antibodies, respectively. The antibody boosting occurred exclusively in cytomegalovirus (CMV) IgG-positive participants. CMV IgG-positive participants also had higher VZV IE62-specific CD4+ IFN-.-producing T-cell percentages and VZV-specific antibody titres. The protective effect of re-exposure to chickenpox is likely limited, as boosting only occurred in 17-25% of the VZV re-exposed grandparents and for less than one year. This work was supported by grants of the Research Foundation Flanders (predoctoral fellowship to B.O.; postdoctoral fellowship to E.L.; project grants G.0409.12N and G.0903.13N); the Hercules Foundation-Belgium and the University of Antwerp (Concerted Research Action; predoctoral fellowships to J.V.D.B. and A.V.; Methusalem funding). |
| Databáze: | OpenAIRE |
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