Different Cortical Gyrification Patterns in Alzheimer's Disease and Impact on Memory Performance
| Autor: | Christian Stephan-Otto, Federica Lombardini, Antonio Callén, Christian Núñez, Alzheimer’s Disease Neuroimaging Initiative, Yaroslau Compta |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Neuroimaging Neuropsychological Tests Insular cortex Temporal lobe 03 medical and health sciences Cognition 0302 clinical medicine Atrophy Alzheimer Disease Memory Image Processing Computer-Assisted medicine Humans Cognitive Dysfunction Gyrification Aged Aged 80 and over Cerebral Cortex business.industry Middle Aged medicine.disease Entorhinal cortex Magnetic Resonance Imaging Cross-Sectional Studies 030104 developmental biology Neurology Disease Progression Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery Alzheimer's Disease Neuroimaging Initiative |
| Zdroj: | Annals of Neurology. 88:67-80 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.25741 |
| Popis: | Objective The study of cortical gyrification in Alzheimer's disease (AD) could help to further understanding of the changes undergone in the brain during neurodegeneration. Here, we aimed to study brain gyrification differences between healthy controls (HC), mild cognitive impairment (MCI) patients, and AD patients, and explore how cerebral gyrification patterns were associated with memory and other cognitive functions. Methods We applied surface-based morphometry techniques in 2 large, independent cross-sectional samples, obtained from the Alzheimer's Disease Neuroimaging Initiative project. Both samples, encompassing a total of 1,270 participants, were analyzed independently. Results Unexpectedly, we found that AD patients presented a more gyrificated entorhinal cortex than HC. Conversely, the insular cortex of AD patients was hypogyrificated. A decrease in the gyrification of the insular cortex was also found in older HC participants as compared with younger HC, which argues against the specificity of this finding in AD. However, an increased degree of folding of the insular cortex was specifically associated with better memory function and semantic fluency, only in AD patients. Overall, MCI patients presented an intermediate gyrification pattern. All these findings were consistently observed in the two samples. Interpretation The marked atrophy of the medial temporal lobe observed in AD patients may explain the increased folding of the entorhinal cortex. We additionally speculate regarding alternative mechanisms that may also alter its folding. The association between increased gyrification of the insular cortex and memory function, specifically observed in AD, could be suggestive of compensatory mechanisms to overcome the loss of memory function. ANN NEUROL 2020 ANN NEUROL 2020;88:67-80. |
| Databáze: | OpenAIRE |
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