Antagonism of CRF Receptors Prevents the Deficit in Brain Reward Function Associated with Precipitated Nicotine Withdrawal in Rats
| Autor: | Mark S. Gold, Adrie W. Bruijnzeel, George Zislis, Carrie Wilson |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Nicotine medicine.medical_specialty Corticotropin-Releasing Hormone media_common.quotation_subject medicine.medical_treatment Central nervous system Self Administration Receptors Corticotropin-Releasing Hormone Drug Administration Schedule Reward Internal medicine Mecamylamine medicine Animals Nicotinic Agonists Rats Wistar media_common Pharmacology Behavior Animal Dose-Response Relationship Drug Antagonist Abstinence medicine.disease Rats Substance Withdrawal Syndrome Psychiatry and Mental health Endocrinology Nicotine withdrawal medicine.anatomical_structure Smoking cessation Brain stimulation reward Psychology medicine.drug |
| Zdroj: | Neuropsychopharmacology. 32:955-963 |
| ISSN: | 1740-634X 0893-133X |
| Popis: | Nicotine dependence is a chronic mental illness that is characterized by a negative affective state upon tobacco smoking cessation and relapse after periods of abstinence. It has been hypothesized that cessation of nicotine administration results in the activation of brain corticotropin-releasing factor (CRF) systems that leads to the negative affective state of withdrawal. The aim of our experiments was to investigate the role of brain CRF systems in the deficit in brain reward function associated with the cessation of nicotine administration in rats. The intracranial self-stimulation procedure was used to assess to negative affective aspects of nicotine withdrawal as this procedure can provide a quantitative measure of emotional distress in rats. In the first experiment, mecamylamine induced a dose-dependent elevation in brain reward thresholds in nicotine-treated rats. In the follow-up experiment, it was shown that pretreatment with the corticotropin-receptor antagonist D-Phe CRF((12-41)) prevents the elevations in brain reward thresholds associated with precipitated nicotine withdrawal. In the third experiment, the effect of D-Phe CRF((12-41)) on the elevations in brain reward thresholds associated with spontaneous nicotine withdrawal was investigated. Administration of D-Phe CRF((12-41)) 6 h after the explantation of the nicotine pumps, did not result in a lowering of the brain reward thresholds. These findings indicate that antagonism of CRF receptors prevents, but not reverses, the deficit in brain associated with nicotine withdrawal. These data provide support for the hypothesis that a hyperactivity of brain CRF systems may at least partly mediate the initiation of the negative affective aspects of nicotine withdrawal. |
| Databáze: | OpenAIRE |
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