SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation
| Autor: | Zong-Bo Wei, Wei Li, Zengqiang Yuan, Corinne Beurrier, Chanjuan Hao, Zhe Zhang, Li Yu, Florence Jaouen, Meisheng Ma, Yefeng Yuan, Quan Chen |
|---|---|
| Přispěvatelé: | Institut de Neurosciences de la Timone (INT), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), School of Materials Science and Engineering, Shanghai University, Centre de Robotique (CAOR), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Mines Paris - PSL (École nationale supérieure des mines de Paris) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
MESH: Vesicular Transport Proteins Dopamine Vesicular Transport Proteins Autophagy-Related Proteins MESH: Mice Knockout MESH: Nerve Degeneration MESH: Autophagy-Related Proteins Phosphatidylinositol 3-Kinases Mesencephalon MESH: Dopaminergic Neurons MESH: Animals MESH: Beclin-1 MESH: Tyrosine 3-Monooxygenase Mice Knockout Neurodegeneration Dopaminergic neurodegeneration BECN1 Cell biology Ventral tegmental area Parkinson disease medicine.anatomical_structure MESH: Monosaccharide Transport Proteins Beclin-1 [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] BECN1-ATG14-PIK3C3 complex medicine.medical_specialty autophagy Monosaccharide Transport Proteins Tyrosine 3-Monooxygenase Basic Research Papers MESH: Class III Phosphatidylinositol 3-Kinases Substantia nigra MESH: Dopamine Biology 03 medical and health sciences dopaminergic neuron Internal medicine medicine Animals MESH: Autophagy Molecular Biology SLC35D3 Tyrosine hydroxylase Pars compacta Dopaminergic Neurons Ventral Tegmental Area Autophagy Cell Biology MESH: Mesencephalon medicine.disease Class III Phosphatidylinositol 3-Kinases 030104 developmental biology Endocrinology nervous system MESH: Phosphatidylinositol 3-Kinases Nerve Degeneration MESH: Ventral Tegmental Area |
| Zdroj: | Autophagy Autophagy, Taylor & Francis, 2016, 12 (7), pp.1168-1179. ⟨10.1080/15548627.2016.1179402⟩ Autophagy, 2016, 12 (7), pp.1168-1179. ⟨10.1080/15548627.2016.1179402⟩ |
| ISSN: | 1554-8627 1554-8635 |
| DOI: | 10.1080/15548627.2016.1179402⟩ |
| Popis: | International audience; Searching for new regulators of autophagy involved in selective dopaminergic (DA) neuron loss is a hallmark in the pathogenesis of Parkinson disease (PD). We here report that an endoplasmic reticulum (ER)-associated transmembrane protein SLC35D3 is selectively expressed in subsets of midbrain DA neurons in about 10% TH (tyrosine hydroxylase)-positive neurons in the substantia nigra pars compacta (SNc) and in about 22% TH-positive neurons in the ventral tegmental area (VTA). Loss of SLC35D3 in ros (roswell mutant) mice showed a reduction of 11.9% DA neurons in the SNc and 15.5% DA neuron loss in the VTA with impaired autophagy. We determined that SLC35D3 enhanced the formation of the BECN1-ATG14-PIK3C3 complex to induce autophagy. These results suggest that SLC35D3 is a new regulator of tissue-specific autophagy and plays an important role in the increased autophagic activity required for the survival of subsets of DA neurons. |
| Databáze: | OpenAIRE |
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