Adrenergic regulation of alpha-MSH secretion in man: evidence for a stimulatory role of beta-receptors
| Autor: | V. D'alessandro, Paolo Piero Limone, Innocenzo Rainero, T. De Gennaro, Gian Michele Molinatti, C. Ambrogio, Lorenzo Pinessi |
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| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Neuroregulation Adrenergic Blood Pressure Propranolol Peptide hormone Endocrinology Adrenocorticotropic Hormone Proopiomelanocortin Heart Rate Reference Values Internal medicine Isoprenaline Receptors Adrenergic beta alpha-MSH beta-receptors medicine Humans Analysis of Variance biology Isoproterenol General Medicine biology.protein Female Corticotropic cell hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Popis: | In several animal species the catecholamines stimulate the release of α-MSH from the melanotrope cells of the pituitary neurointermediate lobe through β-receptors. The human hypophysis does not include a well-defined intermediate lobe and the methods for measuring α-MSH are often poorly sensitive. Neuroregulation of this hormone in man has thus received little attention. To see whether the adrenergic system is involved in the control of α-MSH secretion and whether the latter is independent of that of other peptides derived from proopiomelanocortin, such as ACTH, we studied the effects on plasma α-MSH-like immunoreactivity (α-MSH-LI). ACTH, and cortisol of some adrenergic drugs active on the β-receptors. Six normal volunteers underwent the infusion of the following drugs: isoproterenol (0.03 μg·kg−1·min−1 for 60 min), propranolol (1 mg·min−1 for 5 min followed by 0.1 mg·min−1 for 115 min), propranolol + isoproterenol (infused between 30 and 90 min of propranolol infusion), placebo (saline solution). Isoproterenol increased α-MSH-LI at 1 5 min (p |
| Databáze: | OpenAIRE |
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