Complete covalent structure of human .beta.-thromboglobulin
| Autor: | Geoffrey S. Begg, Francis J. Morgan, Colin N. Chesterman, Duncan S. Pepper |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Blood Platelets
chemistry.chemical_classification integumentary system Macromolecular Substances Platelet Basic Protein Stereochemistry Protein subunit Beta-Globulins Protein primary structure Biochemistry Peptide Fragments Homology (biology) Amino acid chemistry Beta-thromboglobulin Humans Trypsin Amino Acid Sequence Disulfides Amino Acids Peptide sequence Platelet factor 4 |
| Zdroj: | Biochemistry. 17:1739-1744 |
| ISSN: | 1520-4995 0006-2960 |
| DOI: | 10.1021/bi00602a024 |
| Popis: | The complete primary structure of the platelet-specific protein human beta-thromboglobulin has been determined. beta-Thromboglobulin consists of identical subunits of 81 amino acids, each with a molecular weight of 8851. The amino acid sequence of the beta-thromboglobulin subunit is: Gly-Lys-Glu-Glu-Ser-Leu-Asp-Ser-Asp-Leu-Tyr-Ala-Glu-Leu-Arg-Cys-Met-Cys-Ile-Lys-Thr-Thr-Ser-Gly-Ile-His-Pro-Lys-Asn-Ile-Gln-Ser-Leu-Glu-Val-Ile-Gly-Lys-Gly-Thr-His-Cys-Asn-Gln-Val-Glu-Val-Ile-Ala-Thr-Leu-Lys-Asp-Gly-Arg-Lys-Ile-Cys-Leu-Asp-Pro-Asp-Ala-Pro-Arg-Ile-Lys-Lys-Ile-Val-Gln-Lys-Lys-Leu-Ala-Gly-Asp-Glu-Ser-Ala-Asp. Disulfide bridge-18 to half-cystine-58. The amino acid sequence of beta-thromboglobulin shows a marked homology with that of platelet factor 4. When the sequences are aligned for maximum homology, 42 of the 81 residues of beta-thromboglobulin are identical with those of platelet factor 4, including the position of the four half-cystines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|