In vitro study on role of σB protein in avian reovirus pathogenesis
| Autor: | Bina Mishra, Ashok K. Tiwari, Ravi K Agarwal, Shikha Saxena, Bishnu Prasad Mishra, Tapan K.S. Chauhan, Deepak Kumar, Manas Ranjan Praharaj, Puroshottam Prasad Goswami, Kuldeep Dhama, Asok Kumar Marriappan, Aditya Prasad Sahoo, Ravi Kumar Gandham |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
biology Microarray Microarray analysis techniques Arthritis Transfection biology.organism_classification medicine.disease Virus Microbiology 03 medical and health sciences 030104 developmental biology Oncology arthritis Viral arthritis σB protein medicine Orthoreovirus Gene S3 gene microarray avian reovirus Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Avian reoviruses, members of Orthoreovirus genus was known to cause diseases like tenosynovitis, runting-stunting syndrome in chickens. Among eight structural proteins, the proteins of S-class are mainly associated with viral arthritis but the significance of σB protein in arthritis is not established till date. In this infection pathological condition together with infection of joints often leads to arthritis because joints consists of cartilage which forms lubricating surface between two bones, and has limited metabolic, replicative and repair capacity. To establish the role of σB protein in arthritis, an in-vitro microarray study was conducted consisting four groups viz. virus infected and control; pDsRed-Express-N1-σB and empty pDs-Red transfected, CEF cells. With cut-off value as FC ≥2, p value |
| Databáze: | OpenAIRE |
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