Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity
| Autor: | Bernd Weber, Luke E. Stoeckel, Michel A. Audette, Esther Aarts, Marco Ferrari, Valentina Quaresima, David Val-Laillet, Eric Stice, Miguel Alonso-Alonso, Charles-Henri Malbert |
|---|---|
| Přispěvatelé: | Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Donders Institute for Brain, Cognition and Behaviour, Radboud university [Nijmegen], Department of Epileptology, Rheinische Friedrich-Wilhelms-Universität Bonn, Department of Life, Health and Environmental Sciences, Università degli Studi dell'Aquila [L'Aquila] (UNIVAQ.IT), Massachusetts General Hospital, Harvard Medical School [Boston] (HMS), Beth Israel Deaconess Medical Center, Old Dominion University, US 1395 ANI-SCAN [INRA], Institut National de la Recherche Agronomique (INRA), Oregon Research Institute (ORI), AXA Research Fund, K23DA032612, National Institutes of Health, Charles A. King Trust, 5P30 DK046200, Boston Nutrition and Obesity Research Center (BNORC), P30 DK040561, Nutrition Obesity Research Center at Harvard (NORCH), R01 DK092468, Roadmap Supplement, We 4427/3-1, German Research Council (DFG, The Netherlands Organization for Scientific Research (NWO), Norman E. Zinberg Fellowship in Addiction Psychiatry at Harvard Medical School, McGovern Institute Neurotechnology Program, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Università degli Studi dell'Aquila (UNIVAQ), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Radboud University [Nijmegen], Università degli Studi dell'Aquila = University of L'Aquila (UNIVAQ), Old Dominion University [Norfolk] (ODU), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
GP
globus pallidus daCC dorsal anterior cingulate cortex medicine.medical_treatment imagerie cerebrale CCK cholecystokinin MER microelectrode recording Review TRD treatment-resistant depression 0302 clinical medicine PFC prefrontal cortex Cg25 subgenual cingulate cortex dlPFC dorsolateral prefrontal cortex ComputingMilieux_MISCELLANEOUS 5-HT serotonin Transcranial direct-current stimulation comportement alimentaire Brain Eating disorders Human Neuroimaging Neuromodulation Obesity Electric Stimulation Therapy Electroencephalography Feeding Behavior Humans Neurofeedback Transcranial Magnetic Stimulation Feeding and Eating Disorders Radiology Nuclear Medicine and Imaging Neurology Neurology (clinical) Cognitive Neuroscience vlPFC ventrolateral prefrontal cortex VN vagus nerve fonction cérébrale tRNS transcranial random noise stimulation Neuromodulation (medicine) 3. Good health obésité VNS vagus nerve stimulation VS ventral striatum fMRI functional magnetic resonance imaging CBF cerebral blood flow Radiology lcsh:Computer applications to medicine. Medical informatics fNIRS functional near-infrared spectroscopy lPFC lateral prefrontal cortex 03 medical and health sciences hyperphagia aCC anterior cingulate cortex BED binge eating disorder HHb deoxygenated-hemoglobin Binge eating tDCS transcranial direct current stimulation medicine.disease ADHD attention deficit hyperactivity disorder DTI diffusion tensor imaging vmH ventromedial hypothalamus Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery STN subthalamic nucleus rCBF regional cerebral blood flow HD-tDCS high-definition transcranial direct current stimulation HFD high-fat diet BS bariatric surgery [SDV]Life Sciences [q-bio] BMI body mass index trouble alimentaire human health PD Parkinson's disease PYY peptide tyrosine tyrosine lcsh:RC346-429 BOLD blood oxygenation level dependent LHA lateral hypothalamus Binge-eating disorder DAT dopamine transporter Nuclear Medicine and Imaging ED eating disorders Nac nucleus accumbens O2Hb oxygenated-hemoglobin medicine.diagnostic_test Bulimia nervosa pCC posterior cingulate cortex santé humaine homme lcsh:R858-859.7 cerveau medicine.symptom Psychology EEG electroencephalography B N bulimia nervosa 030209 endocrinology & metabolism vmPFC ventromedial prefrontal cortex food habits VTA ventral tegmental area dTMS deep transcranial magnetic stimulation PET positron emission tomography tACS transcranial alternate current stimulation rtfMRI real-time functional magnetic resonance imaging OFC orbitofrontal cortex VBM voxel-based morphometry rTMS repetitive transcranial magnetic stimulation medicine Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system OCD obsessive–compulsive disorder TMS transcranial magnetic stimulation DBT deep brain therapy MRS magnetic resonance spectroscopy BAT brown adipose tissue ANT anterior nucleus of the thalamus SPECT single photon emission computed tomography AN anorexia nervosa DA dopamine 170 000 Motivational & Cognitive Control DBS deep brain stimulation |
| Zdroj: | NeuroImage : Clinical Neuroimage-Clinical Neuroimage-Clinical, Elsevier, 2015, 8, pp.1-31. ⟨10.1016/j.nicl.2015.03.016⟩ Neuroimage. Clinical, 8, 1-31 NeuroImage. Clinical (8), 1-31. (2015) NeuroImage: Clinical, Vol 8, Iss C, Pp 1-31 (2015) Neuroimage-Clinical, 2015, 8, pp.1-31. ⟨10.1016/j.nicl.2015.03.016⟩ Neuroimage. Clinical, 8, pp. 1-31 |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2015.03.016⟩ |
| Popis: | Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highlight the potential of neuroimaging and neuromodulation in individualized medicine. Third, we will introduce the ethical questions that are concomitant to the emergence of new neuromodulation therapies. Highlights • We review the neural vulnerability factors related to obesity and eating disorders. • We compare the pros and cons of neuroimaging techniques to study eating behavior. • We present non-invasive strategies to modulate food-related brain processes. • We also present invasive neuromodulation methods such as VNS and DBS. • We discuss about neuroimaging and neuromodulation for prevention and therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|