Two Co(II) coordination polymers: magnetic properties and application values against chronic subdural hematoma
| Autor: | Sheng-Long Cao, Juan Shen, Jing-Sen Chen, Yu-Jun Qi, Hai-Ying Hu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Materials science magnetic performances Polymers and Plastics General Chemical Engineering mixed-ligand 02 engineering and technology General Chemistry Polymer Mixed ligand 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Coordination polymers TP1080-1185 Nuclear magnetic resonance chemistry Chronic subdural hematoma chronic subdural hematoma Full Length Article Materials Chemistry Polymers and polymer manufacture 0210 nano-technology Research Article |
| Zdroj: | Designed Monomers and Polymers article-version (VoR) Version of Record Designed Monomers and Polymers, Vol 24, Iss 1, Pp 201-209 (2021) |
| ISSN: | 1568-5551 |
| Popis: | In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are [Co3(opda)3(mbib)4(H2O)4]·2H2O (1, H2opda is 1,2-phenylenediacetic acid) and [Co(mpda)(mbib)]·H2O (2, H2mpda is 1,3-phenylenediacetic acid). The two compounds’ magnetic performances suggest that between the adjacent metal ions, there present the antiferromagnetic coupling. The evaluation of their treatment activity against chronic subdural hematoma was carried out and the relevant mechanism was studied simultaneously. Firstly, before the treatment of compound, the chronic subdural hematoma was generated. Furthermore, the enzyme-linked immunosorbent assay detection kit was implemented and in hematoma capsule, the anti-inflammatory cytokines level and pro-inflammatory cytokines level was detected. Additionally, the cytotoxicity of compounds 1 and 2 on the normal human cells was determined with Cell Counting Kit-8 assay. Above all, we proved compound 1 decreased the pro-inflammatory cytokines content and increased the anti-inflammatory cytokines content in the hematoma capsule, which is much stronger than that of compound 2. Both compounds 1 and 2 showed no cytotoxicity on the normal human cells. |
| Databáze: | OpenAIRE |
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