Epidemiology of Chronic Effects of Traumatic Brain Injury
| Autor: | Mary Jo Pugh, Kristine Yaffe, Jessica Wolfe, Nicole Harmon, Eric M. Prager, Juliet Haarbauer-Krupa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Pediatrics Clinical Trials as Topic business.industry Traumatic brain injury Mental Disorders medicine.disease nervous system diseases Clinical trial 03 medical and health sciences 0302 clinical medicine nervous system Research Design Epidemiology Brain Injuries Traumatic Medicine Humans Cognitive Dysfunction Dementia Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Journal of neurotrauma. 38(23) |
| ISSN: | 1557-9042 |
| Popis: | Although many patients diagnosed with traumatic brain injury (TBI), particularly mild TBI, recover from their symptoms within a few weeks, a small but meaningful subset experience symptoms that persist for months or years after injury and significantly impact quality of life for the person and their family. Factors associated with an increased likelihood of negative TBI outcomes include not only characteristics of the injury and injury mechanism, but also the person's age, pre-injury status, comorbid conditions, environment, and propensity for resilience. In this article, as part of the Brain Trauma Blueprint: TBI State of the Science framework, we examine the epidemiology of long-term outcomes of TBI, including incidence, prevalence, and risk factors. We identify the need for increased longitudinal, global, standardized, and validated assessments on incidence, recovery, and treatments, as well as standardized assessments of the influence of genetics, race, ethnicity, sex, and environment on TBI outcomes. By identifying how epidemiological factors contribute to TBI outcomes in different groups of persons and potentially impact differential disease progression, we can guide investigators and clinicians toward more-precise patient diagnosis, along with tailored management, and improve clinical trial designs, data evaluation, and patient selection criteria. |
| Databáze: | OpenAIRE |
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