| Autor: |
Kang Nyeong Lee, Oh Young Lee, Hoon Jai Chun, Jin Il Kim, Sung Kook Kim, Sang Woo Lee, Kyung Sik Park, Kook Lae Lee, Suck Chei Choi, Jae-Young Jang, Gwang Ha Kim, In-kyung Sung, Moo In Park, Joong Goo Kwon, Nayoung Kim, Jae Jun Kim, Soo Teik Lee, Hyun Soo Kim, Ki Bae Kim, Yong Chan Lee, Myung-Gyu Choi, Joon Seong Lee, Hwoon-Yong Jung, Kwang Jae Lee, Jie-Hyun Kim, Hyunsoo Chung |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
World journal of gastroenterology. 28(44) |
| ISSN: |
2219-2840 |
| Popis: |
Fexuprazan, a novel potassium-competitive acid blocker, reversibly suppresses the KTo compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis (EE).Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight weeks. The primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week 8. The secondary endpoints included the healing rate of EE at week 4, symptom response, and quality of life assessment. Safety profiles and serum gastrin levels were compared between the groups.Of the 263 randomized, 218 completed the study per protocol (fexuprazan 40 mg,Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week 8. We suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
