Effects of cortisol suppression by etomidate on changes in circulating metabolites associated with pelvic surgery
| Autor: | G. M. Hall, S. Lacoumenta, J. L. Paterson, M. A. Myers |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Blood Glucose
Cortisol secretion medicine.medical_specialty Time Factors Hydrocortisone Sterilization Tubal Blood Pressure Anesthesia General Fatty Acids Nonesterified Heart Rate Etomidate Internal medicine Heart rate medicine Humans Infusions Parenteral Pelvic surgery chemistry.chemical_classification business.industry Fatty acid General Medicine Kinetics Anesthesiology and Pain Medicine Blood pressure Plasma cortisol Endocrinology Hematocrit chemistry Lactates Female business medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 30:101-104 |
| ISSN: | 1399-6576 0001-5172 |
| DOI: | 10.1111/j.1399-6576.1986.tb02376.x |
| Popis: | The effects of cortisol suppression by etomidate on the changes in circulating metabolites associated with pelvic surgery were investigated in healthy female patients. The use of etomidate resulted in the inhibition of cortisol secretion for 24 h compared with a control group of patients. However, the inhibition of steroidogenesis was not associated with a significant effect on blood glucose, blood lactate and plasma nonesterified fatty acid values, although the glycaemic response to surgery was consistently less in those patients who received etomidate. Heart rate and arterial pressure were significantly decreased during surgery in the etomidate group compared with the control group, but were similar in the postoperative period when the difference in plasma cortisol between the groups was greatest. The results suggest that cortisol has only a minor role in determining changes in circulating metabolites associated with surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text