Protective effect of L-carnitine in a rat model of retinopathy of prematurity
| Autor: | Sadullah, Keleş, İbrahim, Caner, Orhan, Ateş, Özgiir, Çakici, Fatih, Saruhan, Uğur Yilmaz, Mumcu, Deniz, Ünal, Kadir Şerafettin, Tekgündüz, Ayhan, Taştekin, Ahmet, Hacimüftüoğlu, Nesrin, Gürsans, Hamit Hakan, Alp |
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| Přispěvatelé: | MÜ, Selçuk Üniversitesi, Keles, S, Caner, I, Ates, O, Cakici, O, Saruhan, F, Mumcu, UY, Unal, D, Tekgunduz, KS, Tastekin, A, Hacimuftuoglu, A, Gursan, N, Alp, HH, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Caner, İbrahim |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pathology Serial dilution L-Carnitine Protective Agents oxygen toxicity Serology Rats Sprague-Dawley Tongue Carnitine General & Internal Medicine Malondialdehyde L-carnitine medicine Animals Retinopathy of Prematurity Immunoperoxidase Staining skin and connective tissue diseases Direct fluorescent antibody Cerrahi Tissue microarray Oxygen Toxicity biology business.industry Toxoplasma gondii General Medicine biology.organism_classification Rats Surgery Oxygen Disease Models Animal Oxidative Stress medicine.anatomical_structure Animals Newborn Percoll gradient centrifugation sense organs business Key words: L-carnitine malondialdehyde oxygen toxicity retinopathy of prematurity |
| Zdroj: | Volume: 44, Issue: 3 471-475 Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 1300-0144 |
| DOI: | 10.3906/sag-1301-9 |
| Popis: | WOS: 000334063700020 PubMed: 25558651 Aim: To investigate the effects of L-carnitine (LC) on rats with oxygen-induced retinopathy. Materials and methods: The study was conducted on 40 Sprague Dawley rat pups. The rat pups were randomly divided into 4 groups: group 1 (n = 10), the healthy control group with intraperitoneal 0.1 mL/day physiological saline injection; group 2 (n = 10), exposed to hyperoxygen, did not receive LC but received 0.1 mL/day physiological saline intraperitoneally; group 3 (n = 10), exposed to hyperoxygen and received 100 mg/kg/day LC intraperitoneally; group 4 (n = 10), exposed to hyperoxygen and received 200 mg/kg/day LC intraperitoneally. After postnatal day 20, the rat pups were killed and an histological examination was performed on the eyes, in addition to the detection of plasma malondialdehyde (MDA) levels. Results: The retinal and choroidal histopathological changes due to hyperoxygen were less in group 3 and minimal in group 4 compared with group 2. Compared with the healthy control group, the increase in the MDA levels in group 2 was significant (P < 0.05). Compared with group 2 there was a significant (P < 0.05) decrease in the MDA levels in groups 3 and 4. Conclusion: LC has beneficial effects on oxygen-induced retinopathy in rats in terms of histopathological changes and MDA levels. |
| Databáze: | OpenAIRE |
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