The association between pain and prevalent and incident motoric cognitive risk syndrome in older adults
| Autor: | Henriëtte E. van der Horst, Annette H. Blankenstein, Joe Verghese, Emmeline Ayers, Guusje van der Leeuw |
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| Přispěvatelé: | General practice, APH - Mental Health, APH - Aging & Later Life |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Aging medicine.medical_specialty Pediatrics Health (social science) Pain Logistic regression 03 medical and health sciences Cognition 0302 clinical medicine Risk Factors Epidemiology Prevalence Humans Medicine Dementia 030212 general & internal medicine Cognitive decline Risk factor Gait Aged Pain Measurement Aged 80 and over 030214 geriatrics Proportional hazards model business.industry Incidence Chronic pain Health and Retirement Study medicine.disease Cross-Sectional Studies Female Geriatrics and Gerontology Cognition Disorders business Gerontology hormones hormone substitutes and hormone antagonists |
| Zdroj: | Archives of Gerontology and Geriatrics, 87:103991. Elsevier Ireland Ltd van der Leeuw, G, Ayers, E, Blankenstein, A H, van der Horst, H E & Verghese, J 2020, ' The association between pain and prevalent and incident motoric cognitive risk syndrome in older adults ', Archives of Gerontology and Geriatrics, vol. 87, 103991 . https://doi.org/10.1016/j.archger.2019.103991 |
| ISSN: | 0167-4943 |
| DOI: | 10.1016/j.archger.2019.103991 |
| Popis: | Background The Motoric Cognitive Risk Syndrome (MCR) is a pre-dementia syndrome characterized by subjective cognitive complaints and slow gait in the absence of dementia and mobility disability. Worse cognitive and motoric function is associated with chronic pain in older adults. Our aim was to study the association between pain and prevalent and incident MCR in adults aged 65 years and older. Methods We analyzed the cross-sectional association between severity of pain and prevalent MCR in 3244 older adults participating in the Health and Retirement Study (2008 wave) using logistic regression analysis adjusting for demographic, peripheral, central or biological risk factors. Additionally, we analyzed the longitudinal association between severity of pain and incident MCR in 362 participants in the Central Control of Mobility in Aging Study, using Cox regression analysis. Results The 155 Health and Retirement Study participants with severe pain had an increased risk of prevalent MCR (n = 249), compared to 2245 individuals without pain (adjusted for demographics OR: 2.78, 95 % CI:1.74–4.45). Over a mean follow-up of 3.01 years (SD 1.38), 29 individuals in the Central Control of Mobility in Aging Study developed incident MCR. Older adults with severe pain had over a five times increased risk of developing incident MCR, compared to those without pain even after adjusting for demographic variables (HR: 5.44, 95 % CI: 1.81–16.40). Conclusion Older adults with severe pain have a higher prevalence and incidence of MCR. These findings should be further explored to establish if pain is a potentially modifiable risk factor to prevent cognitive decline. |
| Databáze: | OpenAIRE |
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