Chromatin modulation by oncogenic transcription factors: new complexity, new therapeutic targets
| Autor: | Jonathan D. Licht, Itsaso Hormaeche |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Genetics
Cancer Research Oncogene Proteins Fusion Pioneer factor Polycomb-Group Proteins Promoter E-box Transcription coregulator Cell Biology Biology Chromatin remodeling Chromatin Cell biology Epigenesis Genetic Repressor Proteins Oncology Gene Expression Regulation Histone methyltransferase Neoplasms Histone methylation Histone code Humans Transcription Factors |
| Zdroj: | Cancer cell. 11(6) |
| ISSN: | 1535-6108 |
| Popis: | Oncogenic transcription factors such as PML-RARalpha, RUNX1-MTG8, and others work in large part by the recruitment of inhibitors of gene transcription to target promoters leading to aberrant repression of gene expression. PML-RARalpha, an archetypal chimeric oncoprotein, was previously shown to bring complexes of histone deacetylases (HDACs), histone methyltransferases (HMTases), and DNA methyl transferases (DNMTs) to target genes. In this issue of Cancer Cell, Villa et al. show that the full complement of chromatin machinery can be commandeered by these transcription factors with the polycomb group of proteins representing the newest identified recruit. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|