Preclinical Models for Bladder Cancer Research
| Autor: | Guru Sonpavde, Zheng Zhu, Ai Hong Ma, Chong-Xian Pan, Fan Cheng, Shaoming Zhu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Standard of care medicine.medical_treatment Cystectomy Systemic therapy Article Resection 03 medical and health sciences 0302 clinical medicine In vivo Cell Line Tumor Internal medicine Intravesical instillation medicine Animals Humans Neoplasm Invasiveness Bladder cancer business.industry Hematology medicine.disease Disease Models Animal Administration Intravesical Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Humanized mouse Disease Progression Neoplasm Recurrence Local business 030215 immunology |
| Zdroj: | Hematol Oncol Clin North Am |
| ISSN: | 0889-8588 |
| Popis: | At diagnosis, more than 70% of bladder cancers (BCs) are at the non-muscle-invasive bladder cancer (NMIBC) stages, which are usually treated with transurethral resection followed by intravesical instillation. For the remaining advanced cancers, systemic therapy is the standard of care, with addition of radical cystectomy in cases of locally advanced cancer. Because of the difference in treatment modalities, different models are needed to advance the care of NMIBC and advanced BC. This article gives a comprehensive review of both in vitro and in vivo BC models and compares the advantages and drawbacks of these preclinical systems in BC research. |
| Databáze: | OpenAIRE |
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