Dysregulation of mTOR Signaling after Brain Ischemia
| Autor: | Mario Villa González, Gerardo Martín López, Maria Jose Perez Alvarez |
|---|---|
| Přispěvatelé: | UAM. Departamento de Biología |
| Rok vydání: | 2022 |
| Předmět: |
TOR Serine-Threonine Kinases
Organic Chemistry Mechanistic Target of Rapamycin Complex 2 General Medicine Mechanistic Target of Rapamycin Complex 1 Biología y Biomedicina / Biología Catalysis Brain Ischemia Computer Science Applications Inorganic Chemistry mTOR mTORC1 mTORC2 MCAo brain ischemia glia microglia astrocytes oligodendrocytes neuron Humans Physical and Theoretical Chemistry Molecular Biology Spectroscopy Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences. 23:2814 |
| ISSN: | 1422-0067 |
| Popis: | In this review, we provide recent data on the role of mTOR kinase in the brain under physiological conditions and after damage, with a particular focus on cerebral ischemia. We cover the upstream and downstream pathways that regulate the activation state of mTOR complexes. Furthermore, we summarize recent advances in our understanding of mTORC1 and mTORC2 status in ischemia–hypoxia at tissue and cellular levels and analyze the existing evidence related to two types of neural cells, namely glia and neurons. Finally, we discuss the potential use of mTORC1 and mTORC2 as therapeutic targets after stroke. © 2022 by the authors. Licensee MDPI, Basel, Switzerland |
| Databáze: | OpenAIRE |
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