Changes of platelet antioxidative enzymes during oxidative stress: The protective effect of polyphenol-rich extract from berries ofAronia melanocarpaand grape seeds
| Autor: | Anna Stochmal, Barbara Wachowicz, Wieslaw Oleszek, Magdalena Kedzierska, Beata Olas, Joachim Erler |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Blood Platelets Male Resveratrol medicine.disease_cause Vitaceae Antioxidants Superoxide dismutase chemistry.chemical_compound Phenols Photinia Stilbenes medicine Humans Vitis Food science Cells Cultured Chromatography High Pressure Liquid Flavonoids chemistry.chemical_classification Glutathione Peroxidase biology Plant Extracts Superoxide Dismutase Glutathione peroxidase fungi food and beverages Hydrogen Peroxide Hematology General Medicine Glutathione Catalase biology.organism_classification Oxidative Stress chemistry Biochemistry Polyphenol Fruit Seeds Aronia melanocarpa biology.protein Oxidative stress |
| Zdroj: | Platelets. 22:385-389 |
| ISSN: | 1369-1635 0953-7104 |
| DOI: | 10.3109/09537104.2010.545151 |
| Popis: | Aronia melanocarpa fruits (Rosaceae) and grape seeds (seeds of Vitis vinifera, Vitaceae) are two of the richest plant sources of phenolic substances, and they have been shown to have various biological activities. The aim of the present study was to investigate and compare the action of phenolic extracts (at concentrations 5-100 µg/mL) of two different plants, berries of A. melanocarpa (chokebbery) and grape seeds, on the activities of various antioxidative enzymes, the amount of glutathione (as an important component of redox status) in control the platelets and platelets treated with H(2)O(2) (the strong physiological oxidant) in vitro. The properties of these two tested extracts were also compared with the action of a well characterized antioxidative and antiplatelet commercial monomeric polyphenol - resveratrol. The extract from berries of A. melanocarpa, like the extract from grape seeds, reduced the changes in activities of different antioxidative enzymes (glutathione peroxidase, superoxide dismutase, and catalase) in platelets treated with H(2)O(2). The action of the two tested plant extracts and H(2)O(2) evoked a significant increase of reduced glutathione in platelets compared with platelets treated with H(2)O(2) only. Comparative studies indicate that the two tested plant extracts had similar antioxidative properties, and were found to be more reactive in blood platelets than the solution of resveratrol. |
| Databáze: | OpenAIRE |
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