Unexpected benefit of sorbitol placebo in Mg intervention study of premenstrual symptoms: implications for choice of placebo in RCTs
| Autor: | Paul A. Robinson, K M Bolland, George Marakis, M C De Souza, Ann F. Walker, A. P. Morris |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Urinary system Placebo Gastroenterology law.invention Placebos Premenstrual Syndrome Excretion Random Allocation chemistry.chemical_compound Randomized controlled trial law Internal medicine medicine Humans Sorbitol Magnesium Clinical Trials as Topic Dose-Response Relationship Drug business.industry General Medicine Placebo Effect Crossover study Surgery Clinical trial Dose–response relationship chemistry Research Design Female business |
| Zdroj: | Medical Hypotheses. 58:213-220 |
| ISSN: | 0306-9877 |
| DOI: | 10.1054/mehy.2001.1407 |
| Popis: | We carried out a randomized, double-blind, crossover study of 85 women, designed to investigate the dose-response of daily Mg supplementation on premenstrual symptoms. Each woman took one of four treatments: Mg (200, 350 or 500 mg/day) or sorbitol (placebo) for 2 months. This was followed by a washout of 1 month, and then each woman received one of the three remaining treatments for a further 2 months. Unexpectedly, sorbitol (1305 mg) reduced anxiety-related and total premenstrual symptoms after 2 months compared with Mg treatments (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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