Control of oxidative damage in rheumatoid arthritis by gold(I)-thiolate drugs
| Autor: | Martin Grootveld, David R. Blake, Tulin Sahinoglu, Andrew W.D. Claxson, Paul Mapp, Cliff Stevens, Rosamund E. Allen, Alexandra Furst, B. Halliwell |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Auranofin
Free Radicals Stereochemistry Pharmacology Biochemistry Arthritis Rheumatoid chemistry.chemical_compound In vivo medicine Humans Hydrogen peroxide chemistry.chemical_classification Molecular Structure Superoxide Free Radical Scavengers Oxygen Disodium aurothiomalate Enzyme Mechanism of action chemistry Antirheumatic Agents Hydroxyl radical Gold medicine.symptom Oxidation-Reduction medicine.drug |
| Zdroj: | Free radical research communications. 10(4-5) |
| ISSN: | 8755-0199 |
| Popis: | The roles of anti-arthritic gold(I)-thiolate drugs such as disodium aurothiomalate (‘Myocrisin’) in the modulation or promotion of oxygen radical-mediated oxidative damage in vivo ate reviewed. In particular, the precise molecular mechanisms by which these novel second-line agents exert their therapeutic effects are discussed in terms of (i) the direct and indirect control of enzymes involved in the generation or scavenging of reactive oxygen speices (ROS) such as superoxide ion, hydrogen peroxide and hydroxyl radical, (ii) the protection of proteins and relevant enzyme systems against attack by ROS and (iii) their direct involvement in the production (at appropriate ‘target’ sites) or scavenging of ROS in vivo. In addition, the role of the orally-effective gold(I)-phosphine complex auranofin in the control of oxidative damage in rheumatoid arthritis is also discussed. |
| Databáze: | OpenAIRE |
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