Relative inhibitory activity of berberine-type alkaloids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice
| Autor: | Mieko Takeuchi, Fumitake Shimada, Shigeki Nakagawa, Tetsuro Ikekawa, Michio Takido, Ken Yasukawa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Berberine 12-O-Tetradecanoylphorbol-13-acetate chemistry.chemical_compound Mice Alkaloids Edema Internal medicine Drug Discovery medicine Animals Inflammation Mice Inbred ICR Chemistry Alkaloid Anti-Inflammatory Agents Non-Steroidal Biological activity Palmatine General Chemistry General Medicine Endocrinology Tetradecanoylphorbol Acetate Female medicine.symptom Caffeine Quercetin |
| Zdroj: | Chemicalpharmaceutical bulletin. 39(6) |
| ISSN: | 0009-2363 |
| Popis: | Forty eight derivatives of berberine-type alkaloids were examined for their inhibition activity against the induction of edema on mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). Berberine had an inhibitory effect against TPA-induced ear edema at a grade corresponding to those of quercetin, caffeine and cepharanthine.berberine derivatives had stronger inhibitory activity than palmatine derivatives. 9-N, N-Diphenylcarbamoyl derivatives of both 9-demethylberberine and 9-demethylpalmatine had rather strong activity. These inhibitory activities are about ten times the activity of the respective mother compounds. Furthermore, 9-N-monophenylcarbamoyl derivatives and N, N-diphenylcarbamoyl chloride are found to have no effect |
| Databáze: | OpenAIRE |
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