Neural responses to acute cocaine administration in the human brain detected by fMRI
| Autor: | Charles Rainey, Peter R. Kufahl, Gaohong Wu, Shi-Jiang Li, Zhu Li, Robert C. Risinger, Alan S. Bloom |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Dopamine Cognitive Neuroscience Blood Pressure Brodmann area 10 Brain mapping Cocaine-Related Disorders Cocaine Heart Rate Image Processing Computer-Assisted Limbic System medicine Humans Infusions Intravenous Prefrontal cortex Cerebral Cortex Behavior Brain Mapping Echo-Planar Imaging Dopaminergic Brain Human brain Associative learning Oxygen medicine.anatomical_structure Neurology Dopaminergic pathways Female Orbitofrontal cortex Psychology Neuroscience Algorithms psychological phenomena and processes |
| Zdroj: | NeuroImage. 28:904-914 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2005.06.039 |
| Popis: | An improved functional MRI (fMRI) method for the reduction of susceptibility artifacts has been utilized to measure blood oxygen level-dependent (BOLD) responses to acute cocaine administration in the human brain of cocaine users. Intravenous administration of cocaine (20 mg/70 kg) activated mesolimbic and mesocortical dopaminergic projection regions and showed temporal positive or negative BOLD responses. These results obtained from human cocaine users supported the involvement of the dopaminergic pathway in cocaine addiction from animal models. In addition, the cocaine administration also induced activations in the hierarchical brain networks in the anterior prefrontal cortex (aPFC) of the Brodmann area 10 (BA10) and orbitofrontal cortex (OFC). It is suggested that the dopaminergic pathways and the hierarchical brain networks may participate in mediating cocaine reward processes, associative learning, motivation, and memory in cocaine addiction in the human brain. |
| Databáze: | OpenAIRE |
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