In vivo production of interferon β by human Tenon's fibroblasts; a possible mediator for the development of chronic conjunctival inflammation
| Autor: | Peng T. Khaw, Dilani Siriwardena, L Chang, Jonathan G Crowston, M R Wilkins, Arne N. Akbar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_treatment T cell T-Lymphocytes Inflammation Apoptosis Trabeculectomy Cell Communication Pathogenesis Cellular and Molecular Neuroscience Immune system Interferon medicine Humans Fibroblast Aged Aged 80 and over Immunity Cellular business.industry Glaucoma Interferon-beta Fibroblasts Middle Aged Conjunctivitis Sensory Systems Ophthalmology medicine.anatomical_structure Cytokine Immunology Chronic Disease Female medicine.symptom Wound healing business Conjunctiva Scientific Correspondence medicine.drug |
| Popis: | Background: Chronic inflammation may develop from failure of the immune system to deactivate itself during resolution of the wound healing response, and is recognised as a major risk factor for trabeculectomy failure. Fibroblast/T cell interactions may contribute to aggressive scarring. Our previous research showed that in vitro human Tenon's fibroblast produced interferon β was responsible for preventing T cell apoptosis, suggesting that this interaction could contribute to the development of chronic inflammation. Methods: Immunohistological techniques were used to investigate the in vivo components of this particular fibroblast/T cell interaction in conjunctival biopsies from glaucoma patients undergoing filtration surgery. Results: Fibroblast produced interferon β and T lymphocytes were identified in human conjunctiva. Conclusion: The components of fibroblast mediated prevention of T cell apoptosis were identified in vivo, suggesting that the development of this interaction is possible and that it may contribute to the development of chronic inflammation and excessive scarring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|