Intramuscular treatment of migraine attacks using diclofenac sodium: a crossover clinical trial
| Autor: | Marco Poggioni, E. Del Bene, V. Maresca, U. Garagiola |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Drug
Adult Male Diclofenac Adolescent medicine.medical_treatment media_common.quotation_subject Migraine Disorders Placebo Biochemistry Injections Intramuscular 03 medical and health sciences 0302 clinical medicine Double-Blind Method Medicine Humans media_common Chemotherapy Clinical Trials as Topic business.industry Biochemistry (medical) Cell Biology General Medicine Diclofenac Sodium Middle Aged medicine.disease Crossover study Clinical trial Migraine 030220 oncology & carcinogenesis Anesthesia Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of international medical research. 15(1) |
| ISSN: | 0300-0605 |
| Popis: | This was a double-blind clinical trial, with a crossover design, to compare the efficacy of a non-steroidal anti-inflammatory drug, diclofenac sodium, intramuscularly administered, and placebo in the treatment of migraine attacks. The drug was administered to 40 patients once a day in three consecutive migraine attacks. If pain still remained after 6 h following administration the patient was given a 100 mg diclofenac sodium suppository, in open condition. Evaluation was by a complete medical examination performed by the physician and by the patient completing a specially designed self-assessment card. A total of eight patients dropped out of the trial (all during placebo administration): three due to poor compliance, four for refusal to continue and one because no further migraine attacks developed. Results were analysed after having checked the absence of both period and carry-over effects. In all cases diclofenac sodium was more effective than placebo ( P < 0.01). This was also confirmed by data obtained from the patient self-assessment cards ( P < 0.001) and by preferences expressed by patients at the end of the trial ( P < 0.001). Tolerance to the drug was similar to that of placebo. |
| Databáze: | OpenAIRE |
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