Role of citron kinase in dendritic morphogenesis of cortical neurons
| Autor: | Ferdinando Di Cunto, Sara Imarisio, Roberta Curtetti, Vania Broccoli, Fiorella Altruda, Simona Guazzone, Alessandro Vercelli, Alessandro Bulfone, Lorenzo Silengo, Luciana Ferrara |
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| Předmět: |
RHOA
Cellular differentiation Mutant Morphogenesis GTPase Protein Serine-Threonine Kinases Mice medicine Tumor Cells Cultured Animals Cytoskeleton Cerebral Cortex Mice Knockout Neurons biology General Neuroscience Intracellular Signaling Peptides and Proteins Gene Expression Regulation Developmental Cell Differentiation Dendrites Cell biology medicine.anatomical_structure Cerebral cortex biology.protein Neuroscience Cytokinesis |
| Zdroj: | Europe PubMed Central |
| Popis: | Small GTPases of the rho family regulate the extensive rearrangements of the cytoskeleton that characterize neuronal differentiation. Citron kinase is a target molecule for activated rhoA, previously implicated in control of cytokinesis. We have found that, in addition, it could play an important role in modulating the extension of neuronal processes. Using constitutively active and dominant negative mutants, we showed that citron kinase is involved in the morphologic differentiation of N1E-115 neuroblastoma cells induced by serum starvation. More importantly, quantitative analysis of citron kinase knockout cerebral cortex displayed that this molecule may differentially regulate the morphology of the dendritic compartment in corticocollicular versus callosally-projecting pyramidal neurons. |
| Databáze: | OpenAIRE |
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