Long-Term Exposure to [Cr3O(O2CCH2CH3)6(H2O)3]+ in Wistar Rats Fed Normal or High-Fat Diets Does Not Alter Glucose Metabolism
| Autor: | Eric A. Calderon, Betty J. Herring, Hanna Kim, John B. Vincent, Melissa M. Bailey, Brittany M. Miller, Amanda L. Logsdon, Jarrett E. Lockard |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Normal diet Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Carbohydrate metabolism Biology Biochemistry Article Inorganic Chemistry Internal medicine Organometallic Compounds medicine Animals Rats Wistar Insulin Biochemistry (medical) Healthy subjects High fat diet Lipid metabolism General Medicine Metabolism Dietary Fats Diet Rats Glucose Endocrinology Wall thickness |
| Zdroj: | Biological Trace Element Research. 151:406-414 |
| ISSN: | 1559-0720 0163-4984 |
| Popis: | The essentiality of chromium(III) has been the subject of much debate, particularly in healthy subjects. Chromium(III)-containing supplements are widely used for body mass loss, building of lean muscle mass, and improving glucose and lipid metabolism. [Cr(3)O(O(2)CCH(2)CH(3))(6)(H(2)O)(3)](+), Cr3, is one of the most-studied chromium nutritional supplements. The current study evaluates the effects of long-term (15 months) supplementation with Cr3 on body mass and glucose metabolism in Wistar rats on traditional and cafeteria-style (high fat, high carbohydrate) diets. Male Wistar rats were randomly assigned to one of four treatment groups: (1) control diet (milled Harlan Teklad LM-485 rodent diet), (2) control diet+1 mg Cr3/kg body mass/day, (3) a cafeteria-style (CAF) diet (high fat, high carbohydrate), or (4) CAF diet+1 mg Cr3/kg/day. Cr3 supplementation had no effect on fasting blood glucose levels or blood glucose levels in response to glucose and insulin challenges. Rats consuming the CAF+Cr3 diet tended to have a significantly higher body mass than rats consuming the CAF diet, but necropsy results showed no difference in visceral fat or body wall thickness between groups. These data suggest that long-term Cr3 supplementation does not significantly affect body mass in rats consuming a normal diet or glucose levels or metabolism in rats consuming either diet. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink