Iron Absorption in Iron-Deficient Women, Who Received 65 mg Fe with an Indonesian Breakfast, Is Much Better from NaFe(III)EDTA than from Fe(II)SO4, with an Acceptable Increase of Plasma NTBI. A Randomized Clinical Trial
Autor: | Lilik Indrawati, Djumhana Atmakusumah, Ina Susianti Timan, Joannes J.M. Marx, Eka Ginanjar, Iswari Setianingsih, Alida Harahap |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.medical_specialty FeSO4 lcsh:Medicine lcsh:RS1-441 Pharmaceutical Science Placebo Gastroenterology Article law.invention lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Drug Discovery medicine Iron deficient 030212 general & internal medicine non-transferrin-bound iron (NTBI) chemistry.chemical_classification Meal iron deficiency anemia 030109 nutrition & dietetics lcsh:R Food fortification developing countries Iron deficiency NaFeEDTA medicine.disease oral iron therapy chemistry Iron-deficiency anemia Indonesia Transferrin nutrient iron Molecular Medicine |
Zdroj: | Pharmaceuticals Volume 11 Issue 3 Pharmaceuticals, Vol 11, Iss 3, p 85 (2018) |
ISSN: | 1424-8247 |
DOI: | 10.3390/ph11030085 |
Popis: | Plasma non-transferrin-bound iron (NTBI) is potentially harmful due to the generation of free radicals that cause tissue damage in vascular and other diseases. Studies in iron-replete and iron-deficient subjects, receiving a single oral test dose of Fe(II)SO4 or NaFe(III)EDTA with water, revealed that FeSO4 was well absorbed when compared with NaFeEDTA, while only the Fe(II) compound showed a remarkable increase of NTBI. As NaFeEDTA is successfully used for food fortification, a double-blind randomized cross-over trial was conducted in 11 healthy women with uncomplicated iron deficiency. All subjects received a placebo, 6.5 mg FeSO4, 65 mg FeSO4, 6.5 mg NaFeEDTA, and 65 mg NaFeEDTA with a traditional Indonesian breakfast in one-week intervals. Blood tests were carried out every 60 min for five hours. NTBI detection was performed using the fluorescein-labeled apotransferrin method. Plasma iron values were highly increased after 65 mg NaFeEDTA, twice as high as after FeSO4. A similar pattern was seen for NTBI. After 6.5 mg of NaFeEDTA and FeSO4, NTBI was hardly detectable. NaFeEDTA was highly effective for the treatment of iron deficiency if given with a meal, inhibiting the formation of nonabsorbable Fe-complexes, while NTBI did not exceed the range of normal values for iron-replete subjects. |
Databáze: | OpenAIRE |
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