Effect of low molecular weight heparin rectal suppository on experimental ulcerative colitis in mice
| Autor: | Hui-Fei Cui, Jichao Cao, Xueliang Jiang, Jun-Yong Luo |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Pathology Colon medicine.drug_class Low molecular weight heparin Rectum Suppository Gastroenterology Polyethylene Glycols Mice Administration Rectal Internal medicine Animals Medicine Colitis Peroxidase Pharmacology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Suppositories Anti-Inflammatory Agents Non-Steroidal Anticoagulant General Medicine Heparin Heparin Low-Molecular-Weight medicine.disease Ulcerative colitis medicine.anatomical_structure Rectal administration Factor Xa Cytokines Colitis Ulcerative Female business medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy. 64:441-445 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2010.01.013 |
| Popis: | The objective of this study was to investigate the effect and possible mechanism of rectally administered low molecular weight heparin (LMWH) on experimental ulcerative colitis. LMWH rectal suppository was prepared and its efficacy was studied by macroscopical and histological scoring systems as well as myeloperoxidase activity. Serum levels, including tumor necrosis factor-α (TNFα), interleukin-6 (IL-6) and a link factor of blood coagulation and inflammation factor Xa (FXa) were assayed by enzyme-linked immunosorbent assay. The expression of Musashi-1 (as an intestinal stem cell marker) in the colons was assessed by immunohistochemical analysis. The results showed that LMWH rectal suppository significantly decreased serum levels of TNF-α, IL-6 as well as FXa, while increased the expression of Musashi-1 in colon compared with acetic acid induced ulcerative colitis model group. All these preliminary results indicate LMWH rectal suppository is promising for treatment of ulcerative colitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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