Bacteriological findings and antimicrobial susceptibility in chronic sinusitis with nasal polyp

Autor: Hyun Jun Kim, Jong-Bum Yoo, Joo-Heon Yoon, Jung-Whan Song, Kyungwon Lee
Rok vydání: 2006
Předmět:
Adult
Male
medicine.medical_specialty
Pathology
Haemophilus Infections
Meatus
Adolescent
Maxillary sinus
medicine.drug_class
Penicillin Resistance
Statistics as Topic
Antibiotics
Microbial Sensitivity Tests
Amoxicillin-Potassium Clavulanate Combination
medicine.disease_cause
Gastroenterology
Pneumococcal Infections
Haemophilus influenzae
Bacteria
Anaerobic
Nasal Polyps
Anti-Infective Agents
Internal medicine
Streptococcus pneumoniae
otorhinolaryngologic diseases
Humans
Medicine
Nasal polyps
Child
Sinusitis
Bacteriological Techniques
business.industry
Chronic sinusitis
Bacterial Infections
General Medicine
Maxillary Sinus
Staphylococcal Infections
Maxillary Sinusitis
medicine.disease
Cephalosporins
Nasal Mucosa
Treatment Outcome
medicine.anatomical_structure
Otorhinolaryngology
Chronic Disease
Female
Macrolides
business
Zdroj: Acta Oto-Laryngologica. 126:489-497
ISSN: 1651-2251
0001-6489
DOI: 10.1080/00016480500437385
Popis: We recommend amoxacillin/clavulanate, cephalosporins and macrolides rather than penicillin as the first-line drug in chronic sinusitis with nasal polyps. In cases where there is no improvement of symptoms, cultures should be taken from the middle meatus, followed by appropriate selection of second-line antibiotics according to the sensitivity test results.To investigate the causative bacteria and the antimicrobial susceptibility in patients with chronic sinusitis and nasal polyps in Korea.The bacteriology and antimicrobial susceptibility of maxillary sinus aspirates from 81 patients were evaluated.Aerobes were isolated from 58.0% of the cultures from the middle meatus and from 48.1% of those from the maxillary sinus. Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pneumoniae were the most prevalent aerobic pathogens. Anaerobes were isolated from 8.6% of the cultures from the middle meatus and from 18.5% of the cultures from the maxillary sinus. The predominant anaerobic organisms were Prevotella and Peptostreptococcus in adults but none of them were cultured in children. A high rate of concordance of the middle meatus and maxillary sinus was noted. Monomicrobial infection was most commonly observed. Ampicillin-resistant H. influenzae isolates were cultured in 46% of the cases. Penicillin resistance rates were 93% for Staph. aureus; 25% of Strep. pneumoniae were intermediate and 25% were resistant.
Databáze: OpenAIRE
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