Successful hepatitis B vaccination in patients who underwent transplantation for hepatitis B virus-related cirrhosis: preliminary results
| Autor: | Peter Neuhaus, Ruth Neuhaus, Ulrich Bienzle, Matthias Günther |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Liver Cirrhosis HBsAg Cirrhosis medicine.medical_treatment Liver transplantation medicine.disease_cause Antigen Adjuvants Immunologic Recurrence medicine Humans Hepatitis B Vaccines Aged Hepatitis B virus Transplantation Vaccines Synthetic Hepatology business.industry Middle Aged medicine.disease Hepatitis B Liver Transplantation Vaccination Immunization Immunology Antibody Formation Surgery business |
| Zdroj: | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 8(6) |
| ISSN: | 1527-6465 |
| Popis: | Long-term hepatitis B immunoglobulin (HBIg) prophylaxis prevents endogenous hepatitis B virus (HBV) reinfection in the majority of liver transplant recipients. Active hepatitis B vaccination after orthotopic liver transplantation (OLT) in these patients has produced conflicting results to date. On this study, patients who remained hepatitis B surface antigen (HBsAg) negative with passive immunization after OLT for HBV cirrhosis were actively immunized using recombinant HBV antigen (Engerix), together with a novel adjuvant system (monophosphoryl lipid A and a natural saponine molecule). This led to a sustained antibody response to HBsAg (>500 IU/L) in 5 of 10 patients. This antibody response prevented reinfection and allowed termination of prophylactic HBIg substitution for more than 12 months in these patients. |
| Databáze: | OpenAIRE |
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