Acute and chronic effects of intravitreal bevacizumab on lung biomarkers of angiogenesis in the rat exposed to neonatal intermittent hypoxia
| Autor: | Charles L Cai, Kay D. Beharry, Jacob V. Aranda, Thomas J. Duggan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Vascular Endothelial Growth Factor A medicine.medical_specialty genetic structures Angiogenesis VEGF receptors Clinical Biochemistry Gastroenterology Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Retinopathy of Prematurity Intravitreal bevacizumab Hypoxia Molecular Biology Lung biology Neovascularization Pathologic business.industry Gestational age Retinopathy of prematurity Intermittent hypoxia medicine.disease eye diseases Rats Vascular endothelial growth factor Bevacizumab 030104 developmental biology medicine.anatomical_structure 030228 respiratory system chemistry Animals Newborn biology.protein sense organs business Biomarkers |
| Zdroj: | Experimental lung research. 47(3) |
| ISSN: | 1521-0499 |
| Popis: | Intravitreal bevacizumab (Avastin) is an irreversible vascular endothelial growth factor (VEGF) inhibitor used to treat severe retinopathy of prematurity (ROP) in extremely low gestational age neonates (ELGANs). ELGANs who are at the highest risk for developing severe ROP often experience brief intermittent hypoxia (IH) episodes which may cause oxidative damage. We tested the hypothesis that intravitreal Avastin leaks into the systemic circulation during exposure to IH and has adverse effects on biomarkers of pulmonary microvascular maturation, thus leading to pulmonary hemorrhage and long-term pulmonary sequelae.Neonatal rats at postnatal day (PN) 0 (birth) were exposed to either: 1) hyperoxia (50% OAt PN23, Avastin increased lung VEGF, nitric oxide derivatives (NOx), and hypoxia-inducible factor (HIF)These findings prove our hypothesis that intravitreal Avastin penetrates the blood-ocular barrier in IH and alters lung biomarkers of angiogenesis. Avastin targeting of VEGF could affect normal lung development which may be exaggerated under pathologic conditions such as IH, ultimately leading to vascular permeability, vessel rupture, and pulmonary hemorrhage. |
| Databáze: | OpenAIRE |
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