Effect of postmastectomy radiotherapy on pT1-2N1 breast cancer patients with different molecular subtypes☆
| Autor: | Xin-Yuan Guo, Guang-Yi Sun, Hong-Mei Wang, Min Liu, Yu-Jing Zhang, Na Zhang, Yu Tang, Xu-Ran Zhao, Hao Jing, Hui Fang, Ge Wen, Qi-Shuai Guo, Hong-Fen Wu, Xiao-Hu Wang, Chang-Ying Ma, Ye-Xiong Li, Jing Cheng, Mei Shi, Shu-Lian Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Radiotherapy
Breast neoplasm fungi Modified radical mastectomy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Breast Neoplasms Triple Negative Breast Neoplasms General Medicine Molecular subtype Humans Surgery Original Article 1–3 positive lymph nodes Female Radiotherapy Adjuvant Neoplasm Recurrence Local Propensity Score RC254-282 Mastectomy Neoplasm Staging Retrospective Studies |
| Zdroj: | The Breast : Official Journal of the European Society of Mastology Breast, Vol 61, Iss, Pp 108-117 (2022) |
| ISSN: | 1532-3080 0960-9776 |
| Popis: | Objective To clarify the effect of postmastectomy radiotherapy (PMRT) on pT1-2N1 breast cancer patients with different molecular subtypes. Methods We retrospectively analyzed the data of 5442 patients with pT1-2N1 breast cancer treated using modified radical mastectomy in 11 hospitals in China. Univariate, multivariate, and propensity score matching (PSM) analyses were used to evaluate the effect of PMRT on locoregional recurrence (LRR). Results With a median follow-up duration of 63.8 months, the 5-year LRR rates were 4.0% and 7.7% among patients treated with and without PMRT, respectively (p Highlights • PMRT reduces LRR of pT1-2N1 luminal and triple-negative breast cancers. • PMRT has no effect on the LRR of HER2-overexpressing breast cancer. • Different molecular subtypes display different annual LRR patterns. • Late LRR beyond 5 years is observed in luminal breast cancers. |
| Databáze: | OpenAIRE |
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